Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Warner R, Bell D, HER-2 mutations in lung cancer. Reference article, Radiopaedia.org (Accessed on 15 Feb 2025) https://doi.org/10.53347/rID-69172
Human epidermal growth factor receptor 2 (HER-2) mutations may be detected in approximately 3% of lung adenocarcinomas 1.
Radiographic features
CT
Early studies have suggested HER2-mutant tumors exhibit more aggressive features in general and tend to:
- exhibit a locally-invasive behavior compared with KRAS-mutant tumors 3
- show preponderance for pleural retractions compared with KRAS- and EGFR-mutant tumors 3
- present with greater nodal metastatic spread compared KRAS-mutant tumors 3
See also
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1. Pillai RN, Behera M, Berry LD, Rossi MR, Kris MG, Johnson BE, Bunn PA, Ramalingam SS, Khuri FR. HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. (2017) Cancer. 123 (21): 4099-4105. doi:10.1002/cncr.30869 - Pubmed
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2. Shigematsu H, Takahashi T, Nomura M, Majmudar K, Suzuki M, Lee H, Wistuba II, Fong KM, Toyooka S, Shimizu N, Fujisawa T, Minna JD, Gazdar AF. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. (2005) Cancer research. 65 (5): 1642-6. doi:10.1158/0008-5472.CAN-04-4235 - Pubmed
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3. Sawan P, Plodkowski AJ, Li AE, Li BT, Drilon A, Capanu M, Ginsberg MS. CT features of HER2-mutant lung adenocarcinomas. (2018) Clinical imaging. 51: 279-283. doi:10.1016/j.clinimag.2018.05.028 - Pubmed
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4. Shan L, Qiu T, Ling Y, Guo L, Zheng B, Wang B, Li W, Li L, Ying J. Prevalence and Clinicopathological Characteristics of HER2 and BRAF Mutation in Chinese Patients with Lung Adenocarcinoma. (2015) PloS one. 10 (6): e0130447. doi:10.1371/journal.pone.0130447 - Pubmed
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