Leukocoria

Leukocoria (also spelled as leucocoria or leukokoria) refers to an abnormal white reflection from the retina. Despite its colour, the reflection is related to the familiar red-eye effect. Usually, when a light is shone through the iris, the retina appears red to the observer. In leukocoria, the retina abnormally appears white.

Pathology

Causes

The top 4 causes of leukocoria are:

  1. retinoblastoma: ~58%
  2. persistent hyperplastic primary vitreous: ~28%
  3. Coats disease: ~16%
  4. larval granulomatosis: ~16%

As with anything, causes can be considered using a surgical sieve approach.

Tumours
Developmental
Infection
Degenerative
Trauma
Associations

Leukocoria can be seen in the normal-sized eye or associated with microphthalmia.

Share Article

Article Information

rID: 5000
System: Head & Neck
Section: Gamuts
Tag: eye
Synonyms or Alternate Spellings:
  • Leucocoria

Support Radiopaedia and see fewer ads

  • Drag
    Retinoblastoma - ...
    Photograph: leukocoria due to underlying retinoblastoma
    Drag here to reorder.
  • Drag
    Drusen of the optic nerve head
    Drag here to reorder.
  • Drag
    Persistent hyperplastic primary vitreous
    Drag here to reorder.
  • Drag
    Retinopathy of prematurity
    Drag here to reorder.
  • Updating… Please wait.
    Loadinganimation

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.