Leukocoria (also spelled as leucocoria or leukokoria) refers to an abnormal white reflection from the retina. Despite its colour, the reflection is related to the familiar red-eye effect. Usually, when a light is shone through the iris, the retina appears red to the observer. In leukocoria, the retina abnormally appears white.
The top 4 causes of leukocoria are:
- retinoblastoma: ~58%
- persistent hyperplastic primary vitreous: ~28%
- Coats disease: ~16%
- larval granulomatosis: ~16%
As with anything, causes can be considered using a surgical sieve approach.
- persistent hyperplastic primary vitreous
- Coats disease
- retrolental fibroplasia
- coloboma of choroid or optic disc
- neurocutaneous syndromes
Leukocoria can be seen in the normal-sized eye or associated with microphthalmia.
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