Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Silverstone L, Yap J, et al. Multifocal micronodular pneumocyte hyperplasia. Reference article, Radiopaedia.org (Accessed on 26 Jun 2024) https://doi.org/10.53347/rID-9991
Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare benign hamartomatous proliferation of type II pneumocytes and is mostly seen in association with tuberous sclerosis (TS). It can occur with or without concurrent lymphangiomyomatosis.
HRCT chest
Seen as random faint but relatively well defined small (1-10 mm 1,4) nodular lung parenchymal densities in patients with tuberous sclerosis. These tend to be diffusely scattered throughout the lung in a random distribution with regard to the secondary lobule 1.
Treatment and prognosis
Unlike lymphangiomyomatosis, multifocal micronodular pneumocyte hyperplasia is not progressive and therefore treatment is not required 3.
History and etymology
It was first described by Popper et al. in 1991 7.
General imaging differential considerations include
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1. Ristagno RL, Biddinger PW, Pina EM et-al. Multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. AJR Am J Roentgenol. 2005;184 (3): S37-9. AJR Am J Roentgenol (full text) - Pubmed citation
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2. Koyama M, Johkoh T, Honda O et-al. Chronic cystic lung disease: diagnostic accuracy of high-resolution CT in 92 patients. AJR Am J Roentgenol. 2003;180 (3): 827-35. AJR Am J Roentgenol (full text) - Pubmed citation
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3. Umeoka S, Koyama T, Miki Y et-al. Pictorial review of tuberous sclerosis in various organs. Radiographics. 28 (7): e32. doi:10.1148/rg.e32 - Pubmed citation
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4. Kobashi Y, Sugiu T, Mouri K et-al. Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia. Jpn. J. Clin. Oncol. 2008;38 (6): 451-4. doi:10.1093/jjco/hyn042 - Pubmed citation
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5. Cho HH, Shim SS, Kim Y et-al. Sporadic lymphangioleiomyomatosis with multiple atypical adenomatoid hyperplasia: differentiation from multifocal micronodular pneumocyte hyperplasia. Clin Radiol. 2010;65 (9): 765-7. doi:10.1016/j.crad.2010.03.010 - Pubmed citation
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6. Kobashi Y, Sugiu T, Mouri K et-al. Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia. Jpn. J. Clin. Oncol. 2008;38 (6): 451-4. doi:10.1093/jjco/hyn042 - Pubmed citation
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7. Nagar AM, Teh HS, Khoo RN et-al. Multifocal pneumocyte hyperplasia in tuberous sclerosis. Thorax. 2007;63 (2): 186. doi:10.1136/thx.2006.076604 - Pubmed citation
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8. Guinee D, Singh R, Azumi N et-al. Multifocal micronodular pneumocyte hyperplasia: a distinctive pulmonary manifestation of tuberous sclerosis. Mod. Pathol. 1996;8 (9): 902-6. Pubmed citation
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9. Pannu BS, Apala DR, Kotecha A, Boland JM, Iyer VN. Multifocal micronodular pneumocyte hyperplasia (MMPH) in a patient with tuberous sclerosis-evidence for long term stability. (2017) Respiratory medicine case reports. 20: 113-115. doi:10.1016/j.rmcr.2017.01.010 - Pubmed
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