Multifocal micronodular pneumocyte hyperplasia

Last revised by Dr Yuranga Weerakkody on 26 Jul 2021

Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare benign hamartomatous proliferation of type II pneumocytes and is mostly seen in association with tuberous sclerosis (TS). It can occur with or without concurrent lymphangiomyomatosis.

Seen as random faint but relatively well defined small (1-10 mm 1,4) nodular lung parenchymal densities in patients with tuberous sclerosis. These tend to be diffusely scattered throughout the lung in a random distribution with regard to the secondary lobule 1.

Unlike lymphangiomyomatosis, MMPH is not progressive and therefore treatment is not required 3.

It was first described by Popper in 1991 7.

General imaging differential considerations include

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Cases and figures

  • Case 1
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