Multifocal micronodular pneumocyte hyperplasia

Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare benign hamartomatous proliferation of type II pneumocytes and is seen in association with tuberous sclerosis (TS). It can occur with or without concurrent lymphangiomyomatosis.

Seen as random faint but relatively well defined small (1-10 mm 1,4) nodular lung parenchymal densities in patients with tuberous sclerosis. These tends to be diffusely scattered throughout the lung in a random distribution with regard to the secondary lobule 1.

Unlike lymphangiomyomatosis, MMPH is not progressive and therefore treatment is not required 3.

It was first described by Popper et.al in 1991 7.

General imaging differential considerations include

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Article information

rID: 9991
System: Chest
Tag: cases
Synonyms or Alternate Spellings:
  • Multifocal micronodular pneumocyte hyperplasia (MMPH)
  • MMPH

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