Multifocal micronodular pneumocyte hyperplasia

Last revised by Liz Silverstone on 11 Feb 2025

Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare benign hamartomatous proliferation of type II pneumocytes and is mostly seen in association with tuberous sclerosis (TS). It can occur with or without concurrent lymphangiomyomatosis.

Seen as random 1 relatively well defined small (1-10 mm 1,4) nodular lung opacities in patients with tuberous sclerosis.

Unlike lymphangiomyomatosis, multifocal micronodular pneumocyte hyperplasia is not progressive and therefore treatment is not required 3 however they have been observed to regress on mTOR inhibitors.

It was first described by Popper et al. in 1991 7.

General imaging differential considerations include

Cases and figures

  • Case 1
  • Case 2
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