Neurofibromatosis type 2 (mnemonic)

Useful mnemonics for neurofibromatosis type 2 (NF2) are:

  • rule of 2s



In fact, labeling this disorder neurofibromatosis type 2 is a misnomer, because neurofibromas are not a part of its constellation of abnormalities 1.

Rule of 2s
  • neurofibromatosis type 2
  • chromosome 22 (22q12) gene location
  • bilateral vestibular schwannomas
  • presents in 2nd-4th decades (around 20 years)
  • initial prevalence estimated to be 1:200,000, now thought ~1:25,000

Article information

rID: 4968
Section: Mnemonics
Tag: refs
Synonyms or Alternate Spellings:
  • Rule of 2s (mnemonic)
  • MISME (mnemonic)
  • NF2 mnemonic

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Cases and figures

  • Case 1: ependymoma
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  • Case 2: vestibular schwannoma
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