Obstructive jaundice (summary)

Dr Jeremy Jones et al.

Obstructive jaundice represents a set of conditions that cause jaundice by obstructing the flow of bile into the duodenum anywhere along the intrahepatic or extrahepatic biliary tree.

Reference article

This is a summary article; read more in our article on jaundice.

  • epidemiology
    • depends on the underlying cause
  • presentation
    • icterus of skin or sclera
    • itch may be a presenting complaint
    • depending on the cause
  • pathophysiology
    • broadly split into benign and malignant causes
      • benign
        • gallstones (choledocholithiasis)
        • stricture, e.g. primary sclerosing cholangitis
        • external compression, e.g. pancreatic pseudocyst
      • malignant
        • head-of-pancreas carcinoma
        • portal lymphadenopathy
        • other cancer, e.g. cholangiocarcinoma, gallbladder carcinoma
  • investigation
    • ultrasound is almost always the best first test
    • cross-sectional imaging may be helpful, but depend on US findings
  • treatment
    • depends on the underlying cause
  • confirm biliary dilatation
  • determine the level of obstruction
  • if there is a mass
    • characterise the mass lesion
    • look for local invasion or distant spread
Ultrasound

Ultrasound is the first line investigation for the assessment of jaundice. It is a quick and cheap test and effective in diagnosing biliary dilatation in the hands of an experienced operator. It can also help characterise lesions and determine the level of obstruction.

MRI

MRCP (MR cholangiopancreatography) is a specific type of MRI of the abdomen. It looks specifically at the fluid within the biliary tree and is very helpful when determining the level of biliary obstruction.

MRI Liver can be performed to characterise liver lesions and requires the use of IV contrast.

CT

CT is used for the assessment of extrahepatic mass lesions that cause biliary obstruction and also to determine if there is distant spread in suspected malignancy.

Medical student radiology curriculum
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rID: 49965
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Cases and figures

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    Case 1: gallstones on MRCP
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    Case 2: head of pancreas carcinoma
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    Case 3: Gallstones on MRI
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    Case 4: Chronic pancreatitis and pseudocyst
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