Ovarian yolk sac tumour

Dr Craig Hacking and Radswiki et al.

A ovarian yolk sac tumour (also known as an endodermal sinus tumour) is a type ovarian germ cell tumour.

It is a rare malignant ovarian tumour that usually occurs around the second decade of life. It is considered second most common malignant germ cell tumour of the ovary in children 4. However overall occurrence is rare.

They are typically well encapsulated round to oval masses

Associations
Markers
General

The tumour typically manifests as a large, complex pelvic mass that extends into the abdomen and contains both solid and cystic components. The cystic areas are composed of epithelial lined cysts produced by the tumour or of co-existing mature teratomas. Bilaterality is rare.

Pelvic ultrasound

Tends to have both echogenic and hypoechoic components 4.

Pelvic MRI

They can be associated with prominent signal voids on MRI 2. Areas of haemorrhage can also be seen.

These tumours tend to grow rapidly and had a poor prognosis in the past but now prognosis is improved with the use of new treatments (platin or carboplatin, etoposide, bleomycin). Early lymphatic spread as well as invasion can be common.

Germ cell tumours
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Article information

rID: 15285
System: Gynaecology
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Endodermal sinus tumour
  • Ovarian yolk sac tumours
  • Ovarian yolk sac tumor
  • Ovarian yolk sac tumors
  • Yolk sac tumour of the ovary
  • Yolk sac tumour of the ovaryies
  • Yolk sac tumor of the ovary
  • Endodermal sinus tumour of the ovary
  • Endodermal sinus tumor of the ovary
  • Ovarian endodermal sinus tumour
  • Endodermal sinus tumours

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