Ovarian yolk sac tumour

Ovarian yolk sac tumours, also known as endodermal sinus tumours, are a type of ovarian germ cell tumours.

Ovarian yolk sac tumour is a rare malignant ovarian germ cell tumour that usually occurs around the second decade of life. It is considered the most common malignant germ cell tumour of the ovary in children 4. The overall occurrence is rare, however.

They are typically well-encapsulated round to oval masses.

Typically, yolk sac tumours manifest as a large, complex pelvic mass that extends into the abdomen and contains both solid and cystic components. The cystic areas are composed of epithelial lined cysts produced by the tumour or of co-existing mature teratomas. Bilaterality is rare.

Tends to have both echogenic and hypoechoic components 4.

They can be associated with prominent signal voids on MRI 2. Areas of haemorrhage can also be seen.

These tumours tend to grow rapidly and had a poor prognosis in the past, but now the prognosis has improved with the use of new therapies (platin or carboplatin, etoposide, bleomycin). Early lymphatic spread, as well as invasion, is common.

Germ cell tumours
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Article information

rID: 15285
System: Gynaecology
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Endodermal sinus tumour
  • Ovarian yolk sac tumours
  • Ovarian yolk sac tumor
  • Ovarian yolk sac tumors
  • Yolk sac tumour of the ovary
  • Yolk sac tumour of the ovaryies
  • Yolk sac tumor of the ovary
  • Endodermal sinus tumour of the ovary
  • Endodermal sinus tumor of the ovary
  • Ovarian endodermal sinus tumour
  • Endodermal sinus tumours

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