Squamous cell carcinoma (urinary bladder)

A.Prof Frank Gaillard et al.

Squamous cell carcinoma of the urinary bladder is rare and accounts for only ~3-8% 1,2 of all bladder cancers (90% are transitional cell carcinomas) but nevertheless, SCC is the most common type of nontransitional cell carcinoma involving the bladder 2. SCC of the bladder is observed more frequently in Egypt, where schistosomiasis infections are more frequent than, for example, the UK and US. 

SCC of the bladder is most commonly seen in the setting of chronic irritation, such as that seen from bladder stones

These tumors tend to be solitary and large at the time of detection, with muscular wall invasion reported in a high proportion of patients.

Risk factors
  • antecedent infection with schistosomiasis 
  • chronic irritation, e.g. indwelling catheter, bladder calculi
  • chronic infection
  • intravesical BCG
Recurrence Nomogram

Memorial Sloan-Kettering Cancer Center has published online a nomogram for estimating the risk of bladder recurrence 5 years post-surgery (concordance index 0.75) 4.

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Article information

rID: 9845
System: Urogenital
Tag: bladder
Synonyms or Alternate Spellings:
  • SCC of the bladder
  • Bladder SCC
  • Bladder squamous cell carcinoma
  • Squamous cell carcinoma of the bladder
  • Squamous cell carcinoma of the urinary bladder
  • SCC of the urinary bladder

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Cases and figures

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    Case 2 - with extra vesical spread
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    Case 3
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