Tc-99m DTPA

Dr Jeremy Jones et al.

Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging. 

Characteristics

  • photon energy: 140 KeV
  • physical half-life: 6 hours
  • biological half-life: 2.5 hours
  • normal distribution: kidneys (100%)
  • pharmacokinetics
    • uptake by glomerular filtration (100%)
    • first pass filtration: 10-20%
  • excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.
  • target organ: bladder
  • miscellaneous facts:
    • poor quality images with renal insufficiency

Uses, doses and timings

  • renal study
  • adult dose: 15 mCi IV
  • 60 sec flow study; then every 5 minutes for 25 minutes

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Article Information

rID: 13610
System: Urogenital
Synonyms or Alternate Spellings:
  • Technetium-99m diethylene-triamine-pentaacetate (DTPA)
  • DTPA
  • Technetium-99m diethylene-triamine-pentaacetate
  • Tc-99m diethylene-triamine-pentaacetate

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