Amygdala

The amygdala is a very well studied part of the limbic system and forms part of the mesial temporal lobe. 

Gross anatomy

The amygdala is a complex gray matter structure located anterior and superior to the temporal horn of the lateral ventricle and head of the hippocampus. The anterior extension of the amygdala is identified by the entorhinal sulcus. 

Both the amygdala and the hippocampus are derived from the telencephalon. In 1997, Gloor classified the amygdala into three large groups of nuclei ^2,3:

• basolateral
• corticomedial
• central group

Connections

Output fibers

The output fibers of the amygdala is mainly through two efferent fiber systems:

• stria terminalis
• ventral amygdalofugal pathway

The stria terminalis has a semicircular course in the body of the lateral ventricle. The level of the anterior commissure is a very important anatomical landmark because the stria terminalis splits into three parts:

• pre-commissural part
• commissural part
• post-commissural part

The pre-commissural fibers end in the septal region, and the post-commissural fibers end in the nucleus of stria terminalis. The commissural fibers connect the contralateral amygdala via the anterior commissure.

The ventral amygdalofugal pathway arises from the dorsomedial aspect of the amygdala, and courses medially through substantia innominata, anterior perforated substance, and fibers spread into the cerebral cortex, brainstem, mediodorsal thalamus, and hypothalamus. Direct efferent fibers project to the entorhinal cortex as well as the hippocampus ².

Input fibers

The input fibers to the amygdala are mainly represented by sensory fibers, which transfer information from numerous subcortical regions such as the hypothalamus, basal ganglia, septal region, and autonomic centers in the brainstem. Both the ventral amygdalofugal pathway and the stria terminals carry afferent and efferent fibers together. Some input fibers project to the amygdala along the olfactory stria, and directly from the temporal lobe.

Reciprocal fibers

The basal nucleus of Meynert, and the nucleus of the diagonal band project reciprocally to the amygdala along the ventral amygdalofugal pathway ^1,2.

Relations

• superiorly: partly continuous with the inferomedial aspect of the claustrum
• laterally: optic tract
• posteriorly: hippocampus, connected to the tail of the caudate nucleus

Etymology

Amygdala is derived from the Greek amugdalē, meaning almond, as the complex is almond-shaped.