Last revised by Mohammadtaghi Niknejad on 2 Feb 2024

Aspiration occurs if liquid or solid material enters the subglottic lower respiratory tract.

The term aspiration is used if material passes below the level of the vocal folds, i.e. subglottic. If material enters the larynx but remains above the vocal folds, this is called penetration.

The swallowing act is a well-coordinated and complex process, which, once initiated, is largely involuntary. The timely elevation of the hyoid and larynx, as well as the posteroinferior tilt of the epiglottis, ensure that the laryngeal aditus is closed as the bolus of food/drink passes.

Aspiration usually happens during eating or drinking and may occasionally occur in healthy individuals (e.g. when simultaneously talking and eating) and should provoke a vigorous cough reflex. Numerous pathologies can cause laryngopharyngeal dysfunction that predisposes to recurrent aspirations:

Aspirated material and consequential lung pathology can be visualized with chest x-ray or CT. Videofluoroscopic swallow studies allow direct observation and analysis of the aspiration event.

Findings are discussed in the article on pulmonary aspiration diseases.

A videofluoroscopic swallow study can visualize the timing, mechanism and extent of aspiration.

  • predeglutitive: aspiration occurs before the swallowing reflex is initiated

    • lack of bolus control: dorsal leaking, delayed initiation of swallowing reflex

  • intradeglutitive: aspiration occurs during the swallowing act

    • insufficient larynx closure: reduced or delayed elevation of hyoid/larynx, incomplete epiglottic tilt, postoperative status, impaired pharyngeal clearance

  • postdeglutitive: aspiration occurs after the main bolus has passed the pharynx

    • associated with pharyngeal retentions

The severity of aspiration can be graded using the penetration-aspiration scale.1

If a patient aspirates, one important factor is the presence of a sufficient cough reflex. The absence of an appropriate cough reflex (indicating "silent aspiration") may be associated with higher morbidity 2.

See also barium aspiration.

If a patient is at risk of aspiration the study should be performed with low osmolar water-soluble contrast medium (e.g. Omnipaque, Gastromiro). High osmolar contrast media (e.g. Gastrografin) are contraindicated due to the significant risk of flash pulmonary edema. Though aspiration of small amounts of barium sulfate contrast medium is generally not regarded harmful it can cause pulmonary baritosis and aspiration of larger amounts may lead to death.

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Cases and figures

  • Case 1: barium swallow aspiration
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  • Case 2: barium swallow aspiration
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  • Case 3: barium swallow aspiration
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  • Case 4: due to esophageal stricture
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