Breast imaging-reporting and data system (BI-RADS) assessment category 5

Last revised by Mohammad Taghi Niknejad on 2 Dec 2024

BI-RADS 5 lesions under the BI-RADS (breast imaging reporting and data system) refer to breast lesions that are highly suspicious for malignancy, requiring appropriate action to be taken (i.e. biopsy and management as appropriate). BI-RADS 5 lesions have the characteristic morphology of breast cancer with a ≥95% chance of being malignant1.

The implication of a BI-RADS 5 finding, in contrast to BI-RADS 4, is that if the histology is benign, it should be considered discordant with imaging findings, and lesion excision is still advised.

Radiographic features

Mammography

A BI-RADS 5 lesion has the typical imaging features of breast malignancy. On a mammogram, any two of the following features are demonstrated:

  • spiculated or irregular mass

  • high density

  • fine linear or linear branching segmental calcifications

Nipple retraction, skin thickening and evidence of interval growth, if present, would support the diagnosis.

Cases and figures

  • Case 1
  • Case 2
  • Case 3
  • Case 4
  • Case 5
  • Case 6
  • Case 7
  • Case 8
  • Case 9
  • Case 10
  • Case 11
  • Case 12
  • Case 13
  • Case 14
  • Case 15
  • Case 16
  • Case 17
  • Case 18
  • Case 19: bilateral invasive lobular carcinoma
  • Case 20
  • Case 21
  • Case 22
  • Case 23
  • Case 24
  • Case 25: bilateral invasive lobular carcinoma
  • Case 26
  • Case 27
  • Case 28a: mammography
  • Case 28b: ultrasonography
  • Case 29
  • Case 30
  • Case 31: tomosynthesis
  • Case 32
  • Case 33
  • Case 34
  • Case 35
  • Case 36
  • Case 37
  • Case 38
  • Case 39
  • Case 40
  • Case 41: inflammatory carcinoma
  • Case 42: invasive breast carcinoma
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