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At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
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Chronic osteomyelitis is a form of osteomyelitis and is defined as a progressive inflammatory process resulting in bone destruction and sequestrum formation. Bacteria and fungi can cause it. It may present as recurrent or intermittent disease.
It is a result of osteonecrosis caused by disruption of intraosseous and periosteal blood supply during the acute stage of the disease. A dead infected bone fragment becomes separated from viable bone (known as a sequestrum). Infective agents within the devascularised sequestrum become protected from antibiotics and the endogenous immune response, forming a nidus for chronic infection. This may persist for years. It is characterized by increased inflammatory neutrophils, plasma cells, and lymphocytes.
Inhomogeneous osteosclerosis and/or sequestrum formation (necrotic bone) is characteristic of chronic osteomyelitis on plain radiography.