Colpocephaly is a descriptive term to a disproportionate prominence of the occipital horns of the lateral ventricles. It can result from a wide range of congenital insults.
Patient may present with motor abnormalities, cognitive deficit, visual abnormalities, and seizures.
Radiologically, diagnosis of colpocephaly becomes more likely when posterior horn to anterior horn ratio of the lateral ventricle (P/A ratio) is ≥3 2.
P/A ratio also helps to distinguish colpocephaly from the normal pressure hydrocephalus, which is an important differential diagnosis.
History and etymology
The term comes from the Greek: kolpos (hollow) and kephalos (head); and it was coined by the neurologist Paul Ivan Yakovlev and the neuropathologist Richard C. Wadsworth in 1946 1,3.
- 1. Levine D, Trop I, Mehta TS et-al. MR imaging appearance of fetal cerebral ventricular morphology. Radiology. 2002;223 (3): 652-60. doi:10.1148/radiol.2233011336 - Pubmed citation
- 2. Charles C Esenwa, David E Leaf. BMJ Case Reports. 22 May 2013, doi:10.1136/bcr-2013-009505. BMJ Case Reports citation
- 3. Yakolev PI, Wadsworth RC. Schizencephalies; a study of the congenital clefts in the cerebral mantle; clefts with fused lips. J. Neuropathol. Exp. Neurol. 2010;5: 116-30. Pubmed citation