Ectrodactyly (also known as a split hand-split foot malformation, cleft hand or lobster claw hand) is a skeletal anomaly predominantly affecting the hands (although the feet can also be affected). The condition has a highly variable severity.

The estimated incidence is at ~ 1 in 90,000-150,000 births.

It results from a longitudinal deficiency in central digits where the mechanism is thought to be a failure of the median apical ectodermal ridge in the developing limb bud.

The most common mode of transmission is as an autosomal dominant trait, although autosomal recessive and X-linked modes of transmission also have been described.

  • there is a deficiency or absence of one or more central digits of the hand +/- feet
  • characterized by a deep V- or U-shaped central bony defect

General differential considerations include

Article information

rID: 12311
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Split hand
  • Claw hand
  • Lobster claw hand
  • Cleft hand
  • Split hand and foot syndrome
  • Lobster claw deformity
  • Split-hand/split-foot malformation

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Cases and figures

  • Case 1: hands
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  • Case 1: feet
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  • Case 2
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  • Case 3
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  • Case 4: in EEC syndrome
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  • Case 5: limb-mammary syndrome
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