Gene expression classifier

A gene expression classifier (GEC) test is a developing technology in the pathologic analysis of thyroid nodules, using tissue from a fine needle aspiration.

The test is designed to help classify "indeterminate" thyroid nodules, and therefore avoid surgery for indeterminate nodules that are actually benign.

If the GEC test result is benign then the sensitivity of the test is high enough to achieve a negative predictive value of 94-95% in: 

  • atypical or follicular lesion of undetermined significance
  • follicular neoplasm or lesion suggestive of follicular neoplasm 

However, despite the improved classification, there is still a 5-10% risk of missing a malignant nodule on a biopsy sample that shows cytologically indeterminate cells that are suggestive of cancer.  For these patients, repeat FNA or surgical resection should still be considered.

The GEC test does not have a role when there is a definitive result (either benign or malignant) on the original FNA aspiration.


Ultrasound - procedures/interventions
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Article Information

rID: 32246
Tag: thyroid
Synonyms or Alternate Spellings:
  • Afirma

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