Intraosseous ganglion

An intraosseous ganglion (plural: ganglia) is a benign subchondral radiolucent lesion without degenerative arthritis. 

Tends to occur in middle age.

Patients may have mild localized pain.

They are uni-/multilocular cysts surrounded by a fibrous lining, containing gelatinous material.

  1. mucoid degeneration of intraosseous connective tissue perhaps due to trauma/ischemia
  2. penetration of juxtaosseous soft-tissue ganglion (=synovial herniation) into underlying bone (occasionally)

Common locations are:

  • epiphyses of long bones (medial malleolus, femoral head, proximal tibia, carpal bones) 
  • subarticular flat bone (acetabulum)

Typically well-demarcated solitary lytic lesion, with a sclerotic margin. No communication with joint can be demonstrated. 

  • solitary, unilocular or multilocular 2
  • usually sclerotic rim is present

Bone scans demonstrate increased radiotracer uptake (in 10%).

Article information

rID: 1522
Synonyms or Alternate Spellings:
  • Intraosseous ganglia
  • Intraosseous ganglion cyst
  • Intraosseous ganglion cysts

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Cases and figures

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