The World Health Organization (WHO) classification of tumors of the uterine corpus is a commonly used classification system for uterine tumors. It is part of the 5th edition WHO classification of female genital tumors, published in 2020 1.
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Classification
Endometrial epithelial tumors and precursors
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precursor lesions
endometrial hyperplasia without atypia
endometrial atypical hyperplasia / endometrioid intraepithelial neoplasia
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endometrial carcinomas: most common of all uterine malignancies (>90%)
endometrioid carcinoma: most common histological subtype
serous carcinoma: ~10%
clear cell carcinoma: <10%
mixed carcinoma: ~10%
other endometrial carcinomas: rare (includes mesonephric adenocarcinoma (~1%), mesonephric-like adenocarcinoma, squamous cell carcinoma (<5%), mucinous carcinoma)
carcinosarcoma: previously known as a malignant mixed Müllerian tumor (~5% of all uterine malignancies)
Tumor-like lesions
endometrial metaplasia
Mesenchymal tumors of the uterus
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smooth muscle tumors
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endometrial stromal and related tumors
endometrial stromal nodule
low-grade endometrial stromal sarcoma
high-grade endometrial stromal sarcoma
undifferentiated uterine sarcoma
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miscellaneous mesenchymal tumors
uterine tumor resembling ovarian sex cord tumor
other mesenchymal tumors of the uterus: rare (includes vascular tumors, lipomatous tumors, alveolar soft part sarcoma, solitary fibrous tumor, nerve sheath tumors, NTRK sarcomas, giant cell tumor)
Mixed epithelial and mesenchymal tumors
atypical polypoid adenomyoma
adenosarcoma of the uterus
Miscellaneous tumors
central primitive neuroectodermal tumor (PNET) / CNS embryonal tumor
Related pathology
Tumors involving the uterus but classified elsewhere (i.e. not of the uterine corpus):
gestational trophoblastic disease: including gestational choriocarcinoma
uterine lymphoma: rare (primary or secondary)
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local invasion from other tumors:
metastases to the uterus: rare