Metastatic pulmonary calcification
Metastatic pulmonary calcification (MPC) is a form of pulmonary calcification where there is calcium deposition in normal lung pulmonary parenchyma.
It can occur in a variety of benign and malignant disorders such as:
- chronic renal failure: considered commonest cause 5
- primary and secondary hyperparathyroidism
- vitamin D intoxication
- intravenous calcium therapy
- multiple myeloma
- massive osteolysis caused by metastases
Metastatic pulmonary calcification is typically most marked in the upper lobes. This is thought to be due to higher ventilation to perfusion ratio in apices hence less CO2 pressure and more alkaline environment.
It is usually characterised by centrilobular fluffy ground-glass nodular opacities that may or may not appear calcified. Very rarely ring like calcification may be seen 5.
Increase uptake in pulmonary opacities is confirmatory.
Treatment and prognosis
Overall prognosis will depend on the underlying cause.
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