Necrosis (plural: necroses) is defined as unregulated cell death. This is in contrast to apoptosis, which is a form of regulated, or programmed, cell death 1.
Necrosis is the most common type of cell death observed in injury/disease. It occurs when cellular damage is so severe that lysosomal enzymes enter the cytoplasm, causing autodigestion of the cell 1.
The main types of necrosis are:
- coagulative: tissue architecture is preserved
- liquefactive: loss of tissue architecture, formation of liquid/pus
- caseous: most common with tuberculosis; friable, structure less cell debris
- fat necrosis: refers to local areas of fat destruction, commonly encountered in pancreatitis 1
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