Necrosis

Dr Daniel J Bell and Dr Justin Rich et al.

Necrosis (plural: necroses) is defined as unregulated cell death. This is in contrast to apoptosis, which is a form of regulated, or programmed, cell death 1

Necrosis is the most common type of cell death observed in injury/disease. It occurs when cellular damage is so severe that lysosomal enzymes enter the cytoplasm, causing autodigestion of the cell 1

The main types of necrosis are:

  • coagulative: tissue architecture is preserved 
  • liquefactive: loss of tissue architecture, formation of liquid/pus
  • caseous: most common with tuberculosis; friable, structureless cell debris
  • fat necrosis: refers to local areas of fat destruction, commonly encountered in pancreatitis 1

Article information

rID: 73854
Section: Pathology
Synonyms or Alternate Spellings:
  • Necroses

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