Radiation-induced meningiomas

Radiation-induced meningiomas (RIM) are more frequently multiple and have a very long latency. Meningiomas are a much more frequent complication of radiation exposure compared to sarcomas or gliomas.

Epidemiology

The exact incidence of radiation-induced meningiomas is unknown - one study had an incidence of 22% 1. There is increasing incidence of developing RIMs over time, unlike radiation-induced gliomas that have a stable/decreased incidence 5-years post treatment 1. RIM tend to occur in younger patients when compared to spontaneous meningiomas 3.

Pathology

There is a long latency between radiation exposure and diagnosis of RIM - on average ~35 years. They are more likely to be multiple, be more aggressive and have higher rates of recurrence than spontaneous meningiomas 2

Aetiology

Increased incidence of meningiomas has been documented in populations with radiation exposure that has come from therapeutic, diagnostic and environmental exposures 1, 2:

  • whole brain radiotherapy for childhood leukaemia
  • radiotherapy for tinea capitis
  • whole mouth dental radiographs (increased risk in examinations performed pre-1945 when doses were higher)
  • survivors of Hiroshima and Nagasaki atomic bombings
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Article Information

rID: 1952
Section: Pathology
Synonyms or Alternate Spellings:
  • Radiation induced meningiomas
  • Radiation induced meningioma (RIM)

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