Citation, DOI and article data
Meningiomas are extra-axial tumors and represent the most common tumor of the meninges. They are a non-glial neoplasm that originates from the meningocytes or arachnoid cap cells of the meninges and are located anywhere that meninges are found, and in some places where only rest cells are presumed to be located. Although they are usually easily diagnosed and are typically benign with a low rate of recurrence following surgery, there are a large number of histological variants with variable imaging features and, in some instances, more aggressive biological behavior. Also, inaccessibility and poor resectability in difficult anatomic locations like a skull base meningioma complicates their radical cure 31.
A broad division of meningiomas is into primary intradural (which may or may not have a secondary extradural extension) and primary extradural (rare) 18. They can also be classified according to the location (e.g. skull base, spinal, intraosseous, intraventricular, etc.), by histological variants (e.g. clear cell, rhabdoid, etc.), and by etiology (e.g. radiation-induced, etc.).
Typical meningiomas appear as dural-based masses isointense to grey matter on both T1 and T2 weighted imaging enhancing vividly on both MRI and CT. Some of the variants as mentioned earlier can, however, vary dramatically in their imaging appearance.
This article is a general discussion of meningioma focusing on typical primary intradural meningiomas and the imaging findings of intracranial disease. For spinal and primary extradural tumors refer to spinal meningioma and primary extradural meningioma articles respectively. Many of the histological variants are also discussed separately.
Rarely (e.g. 1-2% of cases 27) meningiomas may also arise at ectopic sites (ectopic primary meningioma) such as in head and neck, orbit, nose, paranasal sinus, oropharynx and even places such as the lung.
Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2 when found in young patients.
Many small meningiomas are found incidentally and are entirely asymptomatic. Often they cause concern as they are mistakenly deemed to be the cause of vague symptoms, most frequently headaches. Larger tumors or those with adjacent edema or abutting particularly sensitive structures can present with a variety of symptoms. Most common presentations include 8:
- headache: 36%
- paresis: 22%
- change in mental status: 21%
Meningiomas may also become clinically apparent due to mass effect depending on their location:
- supratentorial: 85-90% 8
- infratentorial: 5-10%
- obstructive hydrocephalus
- cranial nerve deficits
- miscellaneous intradural: <5%
Although dural venous sinus invasion and occlusion does occur, it usually occurs very gradually. Therefore most cases of venous invasion are asymptomatic as collateral veins have had time to enlarge.
Meningiomas are thought to arise from meningocytes or arachnoid cap cells, which themselves arise from pluripotent mesenchymal progenitor cells, which accounts for the unusual location of primary extradural tumors 18,19.
Although the majority of tumors are sporadic, they are also seen in the setting of previous cranial irradiation and of course in patients with neurofibromatosis type II (Merlin gene on Chromosome 22). Additionally, meningiomas demonstrate estrogen and progesterone sensitivity and may grow during pregnancy.
Grading of meningiomas follows the WHO classification for CNS tumors and includes both usual histological features (e.g. mitotic index) as well as a number of histological subtypes, some of which have been associated with more aggressive behavior 7,11,23:
- grade I: 'benign" (70%)
- transitional meningioma (40%): mixed histology, typically containing meningothelial and fibrous components
- meningothelial meningioma (17%)
- fibrous meningioma (7%)
- microcystic meningioma
- psammomatous meningioma
- angiomatous meningioma *
- secretory meningioma
- metaplastic meningioma
- lymphoplasmacytic-rich meningioma
- grade II: "atypical" (30%)
- clear cell meningioma
- chordoid meningioma
- atypical by histological criteria (29%) 11
- 4 to 19 mitoses per ten high-power fields
- infiltration into brain parenchyma **
- 3 or more of the following 5 histologic features: necrosis, sheet-like growth, small cell change, increased cellularity, prominent nucleoli
- grade III: "anaplastic" or "malignant" (~1%)
* Hemangiopericytomas were, until 1993, considered angiomatous meningiomas, but in 2007 WHO classification of CNS tumors they were classified as a separate entity under "Other neoplasms related to the meninges". This again changed in 2016 when the classification was updated. Hemangiopericytomas and solitary fibrous tumors of the dura are considered different manifestations of the same disease, listed under "mesenchymal, non-meningothelial tumors" as a single entry.
** It is important to note, when reading older literature, that in the WHO 2007 classification, infiltration into the brain parenchyma of an otherwise "benign" grade I tumor was sufficient to designate it a grade II tumor. As such, the incidence of grade II tumors increased to ~30% 11.
In general, there are two main macroscopic forms easily recognized in imaging studies:
- globose: rounded, well defined dural masses, likened to the appearance of a fried egg seen in profile (the most common presentation)
- en plaque: extensive regions of dural thickening
The cut surface reflects the various histologies encountered, ranging from very soft to extremely firm in fibrous or calcified tumors. They are usually light tan in coloring, although again this will depend on histological subtypes.
In addition to histological variants, many of which have 'atypical' imaging appearances, a number of 'special examples' of meningiomas are best discussed separately. These include:
- burnt out meningioma
- cystic meningiomas
- intraosseous meningioma
- intraventricular meningioma
- optic nerve sheath meningioma
- radiation-induced meningioma
The remainder of this section focuses on more typical imaging appearances of run-of-the-mill meningiomas.
Plain films no longer have a role in the diagnosis or management of meningiomas. Historically a number of features were observed, including:
- enlarged meningeal artery grooves
- hyperostosis or lytic regions
- displacement of calcified pineal gland/choroid plexus due to mass effect
CT is often the first modality employed to investigate neurological signs or symptoms, and often is the modality which detects an incidental lesion:
- non-contrast CT
- 60% slightly hyperdense to normal brain, the rest are more isodense
- 20-30% have some calcification 8
- post-contrast CT
- 72% brightly and homogeneously contrast enhance 8
- malignant or cystic variants demonstrate more heterogeneity/less intense enhancement
hyperostosis (5%) 23
- typical for meningiomas that abut the base of the skull
- need to distinguish reactive hyperostosis from:
- direct skull vault invasion by adjacent meningioma
- primary intraosseous meningioma
- enlargement of the paranasal sinuses (pneumosinus dilatans) has also been suggested to be associated with anterior cranial fossa meningiomas 20
- lytic/destructive regions are seen particularly in higher grade tumors but should make one suspect alternative pathology (e.g. hemangiopericytoma or metastasis) ref
As is the case with most other intracranial pathology, MRI is the investigation of choice for the diagnosis and characterization of meningiomas. When appearance and location are typical, the diagnosis can be made with a very high degree of certainty. In some instances, however, the appearances are atypical and careful interpretation is needed to make a correct preoperative diagnosis.
Meningiomas typically appear as extra-axial masses with a broad dural base. They are usually homogeneous and well-circumscribed, although many variants are encountered. It seems that the signal intensity of meningiomas on T2-weighted images correlates with the histological subtypes 29.
Signal characteristics of typical meningiomas include:
- T1 C+ (Gd): usually intense and homogeneous enhancement
- usually isointense to grey matter (~50%) 3,8,13
- hyperintense to grey matter (35-40%)
- hypointense to grey matter (10-15%): compared to grey matter and usually correlates with harder texture and more fibrous and calcified contents
- DWI/ADC: atypical and malignant subtypes may show greater than expected restricted diffusion although recent work suggests that this is not useful in prospectively predicting histological grade 15,16
- MR spectroscopy: usually does not play a significant role in diagnosis but can help distinguish meningiomas from mimics. Features include:
- MR perfusion: good correlation between volume transfer constant (k-trans) and histological grade 28
MR tractography: allows the identification of white matter tracts adjacent to the meningioma
- this may aid in preoperative planning for meningioma resection by allowing planning of a safer access route that would result in less residual functional iatrogenic deficits 30
Helpful imaging signs
A number of helpful imaging signs have been described, including:
- CSF cleft sign, which is not specific for meningioma, but helps establish the mass to be extra-axial; loss of this can be seen in grade II and grade III which may suggest brain parenchyma invasion
- dural tail is seen in 60-72% 2 (note that a dural tail is also seen in other processes)
- sunburst or spoke-wheel appearance of the vessels
- white matter buckling sign
- arterial narrowing
- typically seen in meningiomas which encase arteries
- useful sign in parasellar tumors, in distinguishing a meningioma from a pituitary macroadenoma; the latter typically does not narrow vessels
More than half of the meningiomas demonstrate a variable amount of vasogenic edema in adjacent brain parenchyma 24. Correlation between age, gender, tumor size, rapid growth, location (convexity and parasagittal > elsewhere), histologic type, and invasion in the case of malignant meningiomas have been suggested in literature but not yet confirmed. Although in general, the presence of severe adjacent edema is considered more compatible with aggressive meningiomas, in some histologically benign types such as secretory type, edema can be disproportionately larger than the small tumor size.
The underlying mechanism is most likely multifactorial however it has been shown that there is a strong association between the presence and severity of the peritumoral vasogenic edema (i.e. edema index) and expression of the vascular endothelial growth factor (VEGF) or expression of CEA and CK 17,25.
List of some of the proposed underlying mechanisms are:
- venous stasis/occlusion/thrombosis
- compressive ischemia
- aggressive growth/invasion
- parasitization of pial vessels
- histologic subtype: secretory meningioma 25
- vascular endothelial growth factor (VEGF): produced within the meningioma that enters the adjacent parenchyma
- expression of CEA and CK
Catheter angiography is rarely now of diagnostic use but rather is performed for preoperative embolization to reduce intraoperative blood loss and alleviate resection of a tumor. This is especially useful for skull base tumors, or those thought to be particularly vascular (e.g. microcystic variants or those with very large vessels). Particles are favored typically 7-9 days prior to surgery although they are not free of complication, particularly one study showed a high prevalence of complications associated with particles smaller than 45-150 μm, so risks and benefits should be thoroughly assessed 26.
Meningiomas can have a dual blood supply. The majority of tumors are predominantly supplied by meningeal vessels; these are responsible for the sunburst or spoke-wheel pattern observed on MRI/DSA. Some tumors also have a significant pial supply to the periphery of a tumor.
A well known angiographic sign of meningiomas is the mother-in-law sign, in which the tumor contrast blush "comes early, stays late, and is very dense".
Treatment and prognosis
Treatment is usually with surgical excision. If only incomplete resection is possible (especially at the base of the skull) then external-beam radiation therapy can be used 8.
The Simpson grade correlates the degree of surgical resection completeness with symptomatic recurrence.
Recurrence rate varies with grade and length of follow-up 8,21
- grade I = 7-25%
- grade II = 29-52%
- grade III = 50-94%
Metastatic disease is rare but has been reported 8.
History and etymology
The term "meningioma" was first introduced by Harvey Cushing, a renowned American neurosurgeon, in 1922 9,23.
The differential diagnosis generally includes other dural masses as well as some location-specific entities.
The main dural masses to consider include:
- more aggressive often destroying bone
- extensive peripheral vascularity
- more microlobulation
- dural metastases (e.g. breast cancer)
- for other less common differentials see dural masses
Specific location differentials include:
- cerebellopontine angle
- pituitary region
- base of the skull
In the setting of hyperostosis consider:
- 1. Robert I. Grossman, David M. Yousem. Neuroradiology: The Requisites (Requisites in Radiology). (2003) ISBN: 032300508X
- 2. Wallace E. The Dural Tail Sign. Radiology. 2004;233(1):56-57. doi:10.1148/radiol.2331021332
- 3. Elster A, Challa V, Gilbert T, Richardson D, Contento J. Meningiomas: MR and Histopathologic Features. Radiology. 1989;170(3 Pt 1):857-62. doi:10.1148/radiology.170.3.2916043
- 4. Filippi CG, Edgar MA, Uluğ AM et-al. Appearance of meningiomas on diffusion-weighted images: correlating diffusion constants with histopathologic findings. AJNR Am J Neuroradiol. 2001;22 (1): 65-72. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 5. Agrawal V, Ludwig N, Agrawal A, Bulsara K. Intraosseous Intracranial Meningioma. AJNR Am J Neuroradiol. 2007;28(2):314-5. PMC7977404
- 6. Lee W, Chang K, Choe G et al. MR Imaging Features of Clear-Cell Meningioma with Diffuse Leptomeningeal Seeding. AJNR Am J Neuroradiol. 2000;21(1):130-2. PMC7976343
- 7. David N., M.D. Louis (Editor), Hiroko Ohgaki (Editor), Otmar D. Wiestler (Editor) et al. Who Classification of Tumours of the Central Nervous System (Who Classfication of Tumours). (2007) ISBN: 9283224302
- 8. Chandler, William F., Sandler, Howard M. 1956-. Brain Tumors. (1999) ISBN: 019512958X
- 9. Siegelman E, Mishkin M, Taveras J. Past, Present, and Future of Radiology of Meningioma. Radiographics. 1991;11(5):899-910. doi:10.1148/radiographics.11.5.1947324
- 10. Ginsberg L. Radiology of Meningiomas. J Neurooncol. 1996;29(3):229-38. doi:10.1007/BF00165653
- 11. Backer-Grøndahl T, Moen B, Torp S. The Histopathological Spectrum of Human Meningiomas. Int J Clin Exp Pathol. 2012;5(3):231-42. PMC3341686
- 12. Matsushima N, Maeda M, Takamura M, Matsubara T, Taki W, Takeda K. MRI Findings of Atypical Meningioma with Microcystic Changes. J Neurooncol. 2006;82(3):319-321. doi:10.1007/s11060-006-9285-z
- 13. Jörg-Christian Tonn, Manfred Westphal, J. T. Rutka. Oncology of CNS Tumors. (2010) ISBN: 364202873X
- 14. Joung H. Lee. Meningiomas: Diagnosis, Treatment, and Outcome. (2009) ISBN: 1848829108
- 15. Sanverdi S, Ozgen B, Oguz K et al. Is Diffusion-Weighted Imaging Useful in Grading and Differentiating Histopathological Subtypes of Meningiomas? Eur J Radiol. 2012;81(9):2389-2395. doi:10.1016/j.ejrad.2011.06.031
- 16. Santelli L, Ramondo G, Della Puppa A et al. Diffusion-Weighted Imaging Does Not Predict Histological Grading in Meningiomas. Acta Neurochir. 2010;152(8):1315-1319. doi:10.1007/s00701-010-0657-y
- 17. Ding Y, Wang H, Tang K, Hu Z, Jin W, Yan W. Expression of Vascular Endothelial Growth Factor in Human Meningiomas and Peritumoral Brain Areas. Ann Clin Lab Sci. 2008;38(4):344-51. PMID 18988927
- 18. Tokgoz N, Oner Y, Kaymaz M, Ucar M, Yilmaz G, Tali T. Primary Intraosseous Meningioma: CT and MRI Appearance. AJNR Am J Neuroradiol. 2005;26(8):2053-6. PMC8148822
- 19. Kalamarides M, Stemmer-Rachamimov A, Niwa-Kawakita M et al. Identification of a Progenitor Cell of Origin Capable of Generating Diverse Meningioma Histological Subtypes. Oncogene. 2011;30(20):2333-2344. doi:10.1038/onc.2010.609
- 20. Parizel P, Carpentier K, Van Marck V et al. Pneumosinus Dilatans in Anterior Skull Base Meningiomas. Neuroradiology. 2012;55(3):307-311. doi:10.1007/s00234-012-1106-9
- 21. Smith A, Horkanyne-Szakaly I, Schroeder J, Rushing E. From the Radiologic Pathology Archives: Mass Lesions of the Dura: Beyond Meningioma—Radiologic-Pathologic Correlation. Radiographics. 2014;34(2):295-312. doi:10.1148/rg.342130075
- 23. Lee, Joung H.. Meningiomas: Diagnosis, Treatment, and Outcome. (2008) ISBN: 1846285267
- 24. Kim B, Kim M, Kim S, Chang C, Kim O. Peritumoral Brain Edema in Meningiomas : Correlation of Radiologic and Pathologic Features. J Korean Neurosurg Soc. 2011;49(1):26. doi:10.3340/jkns.2011.49.1.26
- 25. Regelsberger J, Hagel C, Emami P, Ries T, Heese O, Westphal M. Secretory Meningiomas: A Benign Subgroup Causing Life-Threatening Complications. Neuro Oncol. 2009;11(6):819-824. doi:10.1215/15228517-2008-109
- 26. Carli D, Sluzewski M, Beute G, van Rooij W. Complications of Particle Embolization of Meningiomas: Frequency, Risk Factors, and Outcome: Fig 1. AJNR Am J Neuroradiol. 2009;31(1):152-154. doi:10.3174/ajnr.a1754
- 27. Huang S, Chen L, Mao Y, Tong H. Primary Pulmonary Meningioma. Medicine. 2017;96(19):e6474. doi:10.1097/md.0000000000006474
- 28. Tamrazi B, Shiroishi M, Liu C. Advanced Imaging of Intracranial Meningiomas. Neurosurg Clin N Am. 2016;27(2):137-143. doi:10.1016/j.nec.2015.11.004
- 29. Nicosia L, Di Pietro S, Catapano M et al. Petroclival Meningiomas: Radiological Features Essential for Surgeons. ecancer. 2019;13. doi:10.3332/ecancer.2019.907
- 30. Kei Yamada, Osamu Kizu, Tsunehiko Nishimura. MR Tractography for Minimally Invasive Neurosurgery. (2020) <a href="https://doi.org/10.1007/4-431-28576-8_9">doi:10.1007/4-431-28576-8_9</a> <span class="ref_v4"></span>
- 31. Mendenhall W, Friedman W, Amdur R, Foote K. Management of Benign Skull Base Meningiomas: A Review. Skull Base. 2004;14(1):53-60. doi:10.1055/s-2004-821364
- 32. Tang H, Sun H, Chen H et al. Clinicopathological Analysis of Metaplastic Meningioma: Report of 15 Cases in Huashan Hospital. Chin J Cancer Res. 2013;25(1):112-8. doi:10.3978/j.issn.1000-9604.2013.01.10