Renal infarction

Radswiki et al.

Renal infarction results from interruption of the normal blood supply to part of, or to the whole kidney. The main imaging differential diagnosis includes pyelonephritis and renal tumours.

The demographics of affected patients will depend on the underlying cause, although as most cases are the result of atherosclerosis and thromboembolism, most patients are older patients. 

The causes of renal infarction include 1-2,4:

Small renal infarcts are often asymptomatic, and evidence of their prior occurrence only found on imaging at a later stage. When larger, patients typically present with acute flank pain and may have haematuria and proteinuria 4.

Although historically plain radiographs intravenous pyelograms (IVP) with tomography were the mainstay of imaging the kidneys, today CT IVP has become the modality of choice and can image nephrolithiasis exquisitely as well as assess the renal vessels and parenchyma. 

CT

In patients who present with atraumatic flank pain with or without haematuria, a CT KUB is often the first test obtained as the differential is renal colic. Acutely the diagnosis is difficult on non-contrast scans, which may only demonstrate subtle swelling and surrounding stranding 1

CT angiograms can visualise the occluded vessel. In the setting of trauma, it is important to assess for associated haematoma at the hilum which may indicate transection. Rarely the renal vein may also be occluded 2.  

Renal infarcts are most easily identified on post contrast images, preferably in the cortical/arterial phase. One or more focal, wedge-shaped parenchymal defects that involve both the cortex and medulla and extend to the capsular surface are demonstrated 1. In cases where the main renal artery is occluded, then the entire kidney fails to enhance 2.  

In ~50% of cases, a thin rim of cortex continues to enhance, due to collateral capsular perfusion 1-3. This is known as the cortical rim sign, and is not usually present immediately after infarction, but can be seen as early as 8 hours after occlusion (typically best seen several days later) 2-3

Occasionally flip-flop enhancement can be seen, where a region of hypoenhancement on early phases becomes hyperattenuating on delayed imaging 3

Ultrasound

Although CT is usually the first investigation of choice, ultrasound may be performed if the clinical presentation is vague. 

In such cases, acute infarction will appear as an absence of perfusion on colour Doppler examination. There will be a complete absence of perfusion when the entire kidney is affected, or it may be patchy if segmental arteries are involved 6. The absence of flow may also be directly visualised in the renal artery and, in rare cases of venous thrombosis causing infarction, the renal vein 6

Over time the regions of infarctions shrink, becoming hyperechoic scars 6

Contrast-enhanced ultrasound may be useful to detect or confirm a diagnosis of renal infarction. Infarcts will appear as wedge-shaped regions of nonperfusion 7.

In cases where infarcts are segmental, only supportive management is required, and the cause of infarction investigated. 

When complete occlusion of the renal artery is present, then attempts to revascularise the kidney can be made, although the results are disappointing, even in patients with short ischaemic times 2. As such, unless patients have a solitary kidney or are pre-morbidly on the brink of renal failure, most renal artery occlusions are treated conservatively. 

It should be noted that some post renal infarct patients who have remaining viable renal tissue but who develop renal arterial stenosis, may develop secondary renovascular hypertension, and may require endovascular intervention 2

The main differential is hypo-enhancement due to infection (pyelonephritis). In these patients the cortical rim sign is absent, and presentation is often different, with inflammatory/infectious symptoms being prominent. 

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Article Information

rID: 12426
Synonyms or Alternate Spellings:
  • Renal infarct
  • Infarction of the kidney
  • Infarction of kidney

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Cases and Figures

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    Renal infarct
    Case 1: with cortical rim sign
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    Case 2
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    Case 3
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     Case 4
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    Case 6
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    Renal artery sten...
    Case 7
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    Case 8: secondary to aortic dissection
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