Dr Henry Knipe and Dr Matt A. Morgan et al.

Thyroseq® is an expanded gene classifier test designed for further evaluation of indeterminate thyroid nodules on fine needle aspiration (FNA). In particular, it is designed to further evaluate nodules that show atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology. It can also be used to risk-stratify nodules that show follicular neoplasm cytology 2.

The test is a multigene next-generation assay that evaluates for multiple mutations in thyroid cancer. Early results suggest that it offers increased sensitivity and specificity over standard gene expression classifier/AFIRMA testing for detection of cancer in these indeterminate nodules. The most recent iteration of the test is version 3 (as of late 2019). It uses DNA, mRNA, and miRNA markers for evaluation.

Interventional procedures

Article information

rID: 56785
System: Head & Neck
Section: Pathology
Synonyms or Alternate Spellings:

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