Dr Daniel J Bell et al.

Alpha-fetoprotein (AFP) is an important plasma protein synthesized by the yolk sac and fetal liver. In adults, its main utility is as a tumor marker, primarily for hepatocellular carcinoma or teratoma. Functionally it is the fetal homologue of albumin i.e. it acts as a major carrier protein in the antenatal circulation. It is encoded by the AFP gene 1.

Alpha-fetoprotein (AFP) elevation 

This may occur in a broad spectrum of conditions:

Alpha-fetoprotein (AFP) reduction

This may be seen in pregnancy. 

AFP reduction may be associated with: 

See also


Article information

rID: 64153
Section: Pathology
Synonyms or Alternate Spellings:
  • Elevated serum alpha-fetoprotein (AFP)
  • Alpha-fetoprotein (AFP)
  • Raised serum alpha-fetoprotein
  • Raised alpha-fetoprotein
  • Altered alpha-fetoprotein
  • Alpha fetoprotein reduction
  • Reduced serum AFP
  • Serum AFP reduction
  • Conditions associated with altered alpha fetoprotein levels
  • Serum AFP elevation
  • Raised AFP
  • Raised serum alpha fetoprotein levels
  • Alpha fetoprotein (AFP) elevation

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