John Cunningham (JC) virus is a ubiquitous double-stranded DNA virus of the polyomaviridae family 1. It is the aetiological agent of the progressive multifocal leukoencephalopathy (PML).
It was reported that ~70% of adults have been exposed to this virus; however, no clinical syndrome has been associated with this acquisition 1.
History and etymology
The virus was first described by Åström et al in 1958 2, and was first isolated in 1971 by Padgett et al. The latter group assigned the name of the patient to the virus 3.
- 1. Bellizzi A, Anzivino E, Rodio DM et-al. New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy. Clin. Dev. Immunol. 2013;2013: 839719. doi:10.1155/2013/839719 - Free text at pubmed - Pubmed citation
- 2. ASTROM KE, MANCALL EL, RICHARDSON EP. Progressive multifocal leuko-encephalopathy; a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin's disease. Brain. 2000;81 (1): 93-111. Pubmed citation
- 3. Padgett BL, Walker DL, ZuRhein GM et-al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet. 1971;1 (7712): 1257-60. Pubmed citation
- 4. Bag AK, Curé JK, Chapman PR et-al. JC virus infection of the brain. AJNR Am J Neuroradiol. 2010;31 (9): 1564-76. doi:10.3174/ajnr.A2035 - Pubmed citation