John Cunningham virus

John Cunningham (JC) virus is a ubiquitous double-stranded DNA virus of the polyomaviridae family 1. It is the aetiological agent of the progressive multifocal leukoencephalopathy (PML).


It was reported that ~70% of adults have been exposed to this virus; however, no clinical syndrome has been associated with this acquisition 1

History and etymology 

The virus was first described by Åström et al. in 1958 2, and was first isolated in 1971 by Padgett et al. The latter group assigned the name of the patient to the virus 3.

Infections of the central nervous system
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Article information

rID: 37530
Section: Pathology
Synonyms or Alternate Spellings:
  • JC virus

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