Solitary lucent lesion of the skull is a relatively frequent finding. The differential is heavily influenced by the patient's age.
Older adult/elderly
- metastasis/malignancy
- epidermoid and dermoid
- hemangioma
- intraosseous meningioma
- solitary fibrous tumor (hemangiopericytoma)
- giant cell tumor (GCT)
- Brown tumor (osteitis fibrosa cystica)
- Paget disease of bone (osteoporosis circumscripta)
- osteomyelitis
- normal variant
- surgical defect, e.g. burr hole, craniectomy
Child/young adult
- eosinophilic granuloma/histiocytosis
- epidermoid/dermoid
- fibrous dysplasia
- hemangioma
- metastasis
- normal variant
- growing skull fracture
- meningocele
- osteomyelitis
- surgical defect
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