Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Feger J, Agammaglobulinemia. Reference article, Radiopaedia.org (Accessed on 08 Dec 2024) https://doi.org/10.53347/rID-181465
Agammaglobulinemia is a rare inherited immunodeficiency disorder, characterized by a complete absence of mature B cells, which can result in severe antibody deficiency and recurrent infections 1. This is in contrast to hypogammaglobulinaemia where there is a reduction in all types of gammaglobulins without a total absence.
It tends to manifest in infants as soon as the protective effect of maternal immunoglobulins wanes at around six months of age.
Types
Agammaglobulinemia can occur in the following types 1-4:
From an imaging perspective, it is important to recognize the effects of multiple infections within the body.
-
1. Pashangzadeh S, Yazdani R, Nazari F, Azizi G, Abolhassani H, Aghamohammadi A. Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management. Endocr Metab Immune Disord Drug Targets. 2020;20(9):1434-47. doi:10.2174/1871530320666200508114349 - Pubmed
-
2. van der Meer J & Zegers B. Agammaglobulinaemia. Neth J Med. 1994;45(6):250-6. - Pubmed
-
3. Shillitoe B & Gennery A. X-Linked Agammaglobulinaemia: Outcomes in the Modern Era. Clin Immunol. 2017;183:54-62. doi:10.1016/j.clim.2017.07.008 - Pubmed
-
4. Bruton O. Agammaglobulinemia. Pediatrics. 1952;9(6):722-8. - Pubmed
Promoted articles (advertising)
Unable to process the form. Check for errors and try again.