Angiomyofibroblastoma-like tumour of scrotum

Dr Amir Rezaee et al.

Angiomyofibroblastoma-like tumour of scrotum is a rare well-defined slow growing mesenchymal extratesticular nonepididymal tumour which rarely seen in perineum and scrotum of older male patients. A similar tumour can occur in the vulval region in females.

In males, they are seen in middle age to elderly patients between 45-75 years old. In the majority of cases it has an indolent and nonaggressive clinical course; however, in minority focal invasion and recurrence has been reported. 

Macroscopic appearance

These tumours appear as superficial well-circumscribed masses with a gray-white to yellow-brown colour.

Microscopic appearance

Angiomyofibroblastoma-like tumours of scrotum demonstrate high vascularity and perivascular fibrinoid hyalinisation. The tumour cells are spindle cells with minimal atypia and low mitotic rate. 

A small amount of fat is seen in 25-56% of cases. 


Positive for vimentin and negative for S100, actin, and CD 34. 


Heterogeneous echotexture and iso i=echoic to the surrounding tissue and subcutaneous fat. 

CT scan

Well circumscribed homogeneous subcutaneous oval mass with possible several small internal hypodense foci.

  • T1: low due to high fibrous contents
  • T2: intermediate heterogeneous signal

Intense post contrast enhancement due to high vascularity of the lesions.

Treatment is wide surgical resection to reduce recurrence rate. 

In the scrotum, the differential includes rare lesions such as:

  • spindle lipoma of scrotum
  • liposarcoma of scrotum
  • solitary fibrous tumour of scrotum
  • leiomyoma of scrotum 
  • aggressive angiomyxoma of scrotum
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Article information

rID: 43881
System: Urogenital
Section: Pathology
Tags: cases, ref
Synonyms or Alternate Spellings:
  • Angiomyofibroblastoma like tumor of scrotum
  • Angiomyofibroblastoma like tumor of the scrotum

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