Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Birbeck granules. Reference article, Radiopaedia.org (Accessed on 05 Jun 2023) https://doi.org/10.53347/rID-98473
Birbeck granules refer to unusual rod-shaped structures specific to Langerhans cells. Their origin and function remain undetermined. Langerin is a crucial component within Birbeck granules.
History and etymology
Birbeck granules were first described by Michael S Birbeck in 1961 3.
Related pathology
- 1. Mc Dermott R, Ziylan U, Spehner D et al. Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates. Mol Biol Cell. 2002;13(1):317-35. doi:10.1091/mbc.01-06-0300 - Pubmed
- 2. Thépaut M, Valladeau J, Nurisso A et al. Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model. Biochemistry. 2009;48(12):2684-98. doi:10.1021/bi802151w - Pubmed
- 3. Birbeck M, Breathnach A, Everall J. An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England. J Invest Dermatol. 1961;37(1):51-64. doi:10.1038/jid.1961.80
- 4. Cells Containing Birbeck Granules (Langerhans Cell Granules) in the Human Thymus. J Electron Microsc (Tokyo). 1970;19(3):271-6. doi:10.1093/oxfordjournals.jmicro.a049713
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