Bowel wall fat deposition

Last revised by Mohamed Saber on 4 Sep 2022

Bowel wall fat deposition refers to the infiltration of the submucosa with fat and usually occurs in chronic processes such as inflammatory bowel disease, causing characteristic fat halo sign on CT images. 

Other differential diagnoses include:

  • normal variant - particularly in obese patients with insulin resistance
  • coeliac disease - especially in the duodenum and jejunum
  • post chemotherapy - cytoreductive chemotherapy for treatment of lymphoma or leukaemia that can be causing acute bowel wall fat deposition. 
  • post radiotherapy - in the rectum
  • graft-versus-host disease

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