Calcification of the globe has many causes, varying from benign to malignant. When calcification is seen in the posterior half of the globe, it could relate to any of the layers (scleral, choroidal or retinal), as it is not possible to separate them out on CT.
Retinal
drusen: 1% population at optic disc (benign)
tuberous sclerosis: "giant drusen", astrocytic hamartomas
Retinochoroidal
chorioretinitis: most commonly following toxoplasmosis
Choroidal
choroidal osteoma: more common in patients with tuberous sclerosis
choroidal angioma: occasionally calcify
Sclerochoroidal
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metastatic calcification: abnormal calcium and phosphate metabolism
dystrophic calcification: abnormal tissues become calcified, despite normal calcium and phosphate metabolism, occasionally seen in the elderly White population, most frequently men
phthisis bulbi: is the end result of major injury to the eye (trauma, infection) with a shrunken calcified "lump" remaining
scleromalacia perforans: rare form of scleritis associated with autoimmune disease
Differential diagnosis
For globe opacification consider:
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