Citation, DOI, disclosures and article data
Citation:
Kearns C, Sharma R, Feger J, Chagoma (cutaneous). Reference article, Radiopaedia.org (Accessed on 11 Oct 2024) https://doi.org/10.53347/rID-192086
Chagoma describes a cutaneous erythematous reactive lesion at the insect bite inoculation site of the Trypanosoma cruzi parasite, the causative agent in Chagas disease 1-3. The lesion appears in the weeks after infection and may then persist for several weeks 1,2.
Brain chagoma is a distinct entity referring to CNS lesions associated with Chagas disease in immunocompromised individuals 4.
The reactive lesion comprises intracellular parasites, lymphocytic infiltrate, and interstitial edema 2,5. Draining lymph nodes may be hyperplastic and also demonstrate parasites 5.
History and etymology
'Chagoma' references Chagas disease with which it is associated, first described in 1909 by the Brazilian Carlos Justiniano Ribeiro Chagas (1879-1934), head of the Oswaldo Cruz Institute and director of the Malaria Control Program 3. He also named the causative agent, Trypanosoma cruzi, after his mentor Oswaldo Cruz.
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1. Bleeker-Rovers C & De Vries H. Dermatologic Manifestations of Systemic Infections. Infect Dis. 2017;:113-121.e1. doi:10.1016/b978-0-7020-6285-8.00013-7
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2. Cobo F. Trypanosomiasis. Imported Infectious Diseases. 2014;:137-53. doi:10.1533/9781908818737.137
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3. Bern C, Messenger L, Whitman J, Maguire J. Chagas Disease in the United States: A Public Health Approach. Clin Microbiol Rev. 2019;33(1). doi:10.1128/cmr.00023-19
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4. Pittella J. Central Nervous System Involvement in Chagas Disease: A Hundred-Year-Old History. Trans R Soc Trop Med Hyg. 2009;103(10):973-8. doi:10.1016/j.trstmh.2009.04.012 - Pubmed
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5. Kirchhoff L. Trypanosoma Species (American Trypanosomiasis, Chagas' Disease). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 2015;:3108-3115.e2. doi:10.1016/b978-1-4557-4801-3.00278-2
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6. Coura J. The Discovery of Chagas Disease (1908-1909): Great Successes and Certain Misunderstandings and Challenges. Rev Soc Bras Med Trop. 2013;46(4):389-90. doi:10.1590/0037-8682-0143-2013 - Pubmed
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