Cronkhite-Canada syndrome

Cronkhite–Canada syndrome is a type of non-hereditary hamartomatouspolyposis syndrome characterised by rash rash, alopecia, and watery diarrhea diarrhea.

Epidemiology

There is a recognised male predilection.Patients Patients typically are middle age, in their 60^th 1.

Clinical presentation

Patients typically present with watery diarrhea and protein losing enteropathy and associated nail atrophy, brownishskinpigmentation, and alopecia³.

Pathology

Characterised by numerous hamartomatous polyps in the digestive tract, with predominant predominant involvement of the stomach, large intestine and, to a lesser extent, small bowel. The exact aetiology is unknown and there is no recognised familial occurrence. Unlike other polyposis syndromes, it is not associated with a malignancy.

Polyps are similar to those of juvenile polyposis except that that the mucosa among CCS polyps is is oedematous and and inflammation of the lamina propria usually present; in contrast,histologically the,histologically the mucosa among juvenile polyps is normal ⁴.

Radiographic features

Fluoroscopy

On barium studies, this syndrome is characterised by characterised by polyposis involving the entire gastrointestinal tract. Gastric and colonic polyposis are both present in 100% of patients with this diagnosis. Small bowel involvement is seen in 50% of patients.

History and etymology

Initially described byL. W Cronkhite and W. JCanada in 1955 ².