Desmin
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Desmin is a muscle-specific protein. It is the main intermediate filament protein and a key component in the cytoskeletal network of muscle cells e.g. in the myocardium, where it is ampler than in the skeletal ormuscle or smooth musclesmuscle. It interacts with other proteins to support the myofibrils at the level of the Z-discs or of the intercalated discs and has a role in mechanochemical signal transmission, power transfer and the maintenance of cellular integrity 1,2. It also serves as a target in immunohistochemistry where it can be used for the characterization of muscle tissue and tumours.
History and etymology
Desmin was first described in 1976 by Lazarides and Hubbard 3.
-<p><strong>Desmin</strong> is a muscle-specific <a href="/articles/proteins">protein</a>. It is the main intermediate filament protein and a key component in the cytoskeletal network of muscle cells e.g. in the <a href="/articles/myocardium">myocardium</a>, where it is ampler than in the skeletal or smooth muscles. It interacts with other proteins to support the myofibrils at the level of the Z-discs or of the intercalated discs and has a role in mechanochemical signal transmission, power transfer and the maintenance of cellular integrity <sup>1,2</sup>. It also serves as a target in <a href="/articles/immunohistochemistry">immunohistochemistry</a> where it can be used for the characterization of <a title="Muscle" href="/articles/skeletal-muscle">muscle tissue</a> and <a title="Tumours" href="/articles/neoplasm-2">tumours</a>.</p><h4>History and etymology</h4><p>Desmin was first described in 1976 by Lazarides and Hubbard <sup>3</sup>.</p>- +<p><strong>Desmin</strong> is a muscle-specific <a href="/articles/proteins">protein</a>. It is the main intermediate filament protein and a key component in the cytoskeletal network of muscle cells e.g. in the <a href="/articles/myocardium">myocardium</a>, where it is ampler than in <a title="Skeletal muscle" href="/articles/skeletal-muscle">skeletal muscle</a> or smooth muscle. It interacts with other proteins to support the myofibrils at the level of the Z-discs or of the intercalated discs and has a role in mechanochemical signal transmission, power transfer and the maintenance of cellular integrity <sup>1,2</sup>. It also serves as a target in <a href="/articles/immunohistochemistry">immunohistochemistry</a> where it can be used for the characterization of <a href="/articles/skeletal-muscle">muscle tissue</a> and <a href="/articles/neoplasm-2">tumours</a>.</p><h4>History and etymology</h4><p>Desmin was first described in 1976 by Lazarides and Hubbard <sup>3</sup>.</p>
References changed:
- 1. Goldfarb L & Dalakas M. Tragedy in a Heartbeat: Malfunctioning Desmin Causes Skeletal and Cardiac Muscle Disease. J Clin Invest. 2009;119(7):1806-13. <a href="https://doi.org/10.1172/jci38027">doi:10.1172/jci38027</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19587455">Pubmed</a>
- 2. Capetanaki Y, Papathanasiou S, Diokmetzidou A, Vatsellas G, Tsikitis M. Desmin Related Disease: A Matter of Cell Survival Failure. Curr Opin Cell Biol. 2015;32:113-20. <a href="https://doi.org/10.1016/j.ceb.2015.01.004">doi:10.1016/j.ceb.2015.01.004</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25680090">Pubmed</a>
- 3. Lazarides E & Hubbard B. Immunological Characterization of the Subunit of the 100 A Filaments from Muscle Cells. Proceedings of the National Academy of Sciences. 1976;73(12):4344-8. <a href="https://doi.org/10.1073/pnas.73.12.4344">doi:10.1073/pnas.73.12.4344</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/1069986">Pubmed</a>
- 1. Goldfarb L & Dalakas M. Tragedy in a Heartbeat: Malfunctioning Desmin Causes Skeletal and Cardiac Muscle Disease. J Clin Invest. 2009;119(7):1806-13. <a href="https://doi.org/10.1172/JCI38027">doi:10.1172/JCI38027</a>
- 2. Capetanaki Y, Papathanasiou S, Diokmetzidou A, Vatsellas G, Tsikitis M. Desmin Related Disease: A Matter of Cell Survival Failure. Curr Opin Cell Biol. 2015;32:113-20. <a href="https://doi.org/10.1016/j.ceb.2015.01.004">doi:10.1016/j.ceb.2015.01.004</a>
- 3. Lazarides E & Hubbard B. Immunological Characterization of the Subunit of the 100 A Filaments from Muscle Cells. Proc Natl Acad Sci U S A. 1976;73(12):4344-8. <a href="https://doi.org/10.1073/pnas.73.12.4344">doi:10.1073/pnas.73.12.4344</a>
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