Follicular lymphoma
Updates to Article Attributes
Follicular lymphoma is athe most common subtype of non-Hodgkin lymphoma(NHL) and is, in fact, the most common type.
Epidemiology
Estimated to account for ~45% of all NHL cases 1. Higher rates in North America and Europe 4.
Pathology
Nodal effacement by closely packed follicles containing small cleaved cells without nucleoli (centrocytes) and larger non-cleaved cells with moderate cytoplasm, open chromatin and multiple nucleoli (centroblasts).
Follicolar lymphoma is categorized into grades according to the number of centroblasts per high-power fields(hpf (HPF) as follows5:
- grade 1: 0-5 centroblasts per
hpfHPF - grade 2: 6-15 centroblasts per
hpfHPF - grade 3: >15 centroblasts per
hpfHPF
Markers
- CD10: positive
- CD5: negative
- CD20: positive
Genetics
Translocation t(14;18) is found in the majority of patients with follicolarfollicular lymphoma.
Complications
Transformation to a more aggressive type of NHL.
Treatment and prognosis
It is often indolent yet incurable with a high prevalence of residual mass post treatment-treatment 2.
See also
-<p><strong>Follicular lymphoma</strong> is a subtype of <a href="/articles/non-hodgkin-lymphoma">non-Hodgkin lymphoma</a> (NHL) and is, in fact, the most common type.</p><h4>Epidemiology</h4><p>Estimated to account for ~45% of all NHL cases <sup>1</sup>. Higher rates in North America and Europe <sup>4</sup>. </p><h4>Pathology</h4><p>Nodal effacement by closely packed follicles containing small cleaved cells without nucleoli (centrocytes) and larger non-cleaved cells with moderate cytoplasm, open chromatin and multiple nucleoli (centroblasts).</p><p>Follicolar lymphoma is categorized into grades according to the number of centroblasts per high-power fields(hpf) as follows<sup>5</sup>:</p><ul>-<li>grade 1: 0-5 centroblasts per hpf</li>-<li>grade 2: 6-15 centroblasts per hpf</li>-<li>grade 3: >15 centroblasts per hpf</li>- +<p><strong>Follicular lymphoma</strong> is the most common subtype of <a href="/articles/non-hodgkin-lymphoma">non-Hodgkin lymphoma</a> (NHL)</p><h4>Epidemiology</h4><p>Estimated to account for ~45% of all NHL cases <sup>1</sup>. Higher rates in North America and Europe <sup>4</sup>. </p><h4>Pathology</h4><p>Nodal effacement by closely packed follicles containing small cleaved cells without nucleoli (centrocytes) and larger non-cleaved cells with moderate cytoplasm, open chromatin and multiple nucleoli (centroblasts).</p><p>Follicolar lymphoma is categorized into grades according to the number of centroblasts per high-power fields (HPF) as follows<sup>5</sup>:</p><ul>
- +<li>grade 1: 0-5 centroblasts per HPF</li>
- +<li>grade 2: 6-15 centroblasts per HPF</li>
- +<li>grade 3: >15 centroblasts per HPF</li>
-</ul><h5>Genetics</h5><p>Translocation t(14;18) is found in the majority of patients with follicolar lymphoma. </p><h5>Complications</h5><p>Transformation to a more aggressive type of NHL.</p><h4>Treatment and prognosis</h4><p>It is often indolent yet incurable with a high prevalence of residual mass post treatment <sup>2</sup>.</p><h4>See also</h4><ul><li><a href="/articles/2008-who-classification-of-tumours-of-haematopoietic-and-lymphoid-tissues">WHO classification of lymphoid neoplasms</a></li></ul>- +</ul><h5>Genetics</h5><p>Translocation t(14;18) is found in the majority of patients with follicular lymphoma. </p><h5>Complications</h5><p>Transformation to a more aggressive type of NHL.</p><h4>Treatment and prognosis</h4><p>It is often indolent yet incurable with a high prevalence of residual mass post-treatment <sup>2</sup>.</p><h4>See also</h4><ul><li><a href="/articles/2008-who-classification-of-tumours-of-haematopoietic-and-lymphoid-tissues">WHO classification of lymphoid neoplasms</a></li></ul>
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