Gadobenate dimeglumine
Updates to Article Attributes
Gadobenate dimeglumine (also known as MultiHanceTM) is an extracellular intravenous contrast agent used in magnetic resonance imaging.
- linear, ionic molecule
- 95-96% renal excretion, 4-5% hepatic excretion
- T1 relaxivity @ 1.5 T: 6.0-6.6
- concentration: 0.5 mmol/ml
- recommended dosage: 0.1 mmol/kg
Indications
As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.
Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances. The hepatobiliary phase but requires a 1-hour delay for imaging acquisition.
Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. Gadofosveset trisodium (Ablavar) has approximately 3-4x the relaxivity of gadobenate dimeglumine, but is considered a blood pool agent and its commercial availability is limited.
The high relaxivity of gadobenate dimeglumine also makes it a preferred agent for imaging:
- combined abdomen and pelvis imaging
- MR enterography
- MR urography
-
pelvisMR perianal fistulaimaging
Gadobenate dimeglumine has been reported as having a low rate of acute adverse reactions (0.17% rate of total adverse effects with <0.01% serious adverse effects) 2.
-</ul><h5>Indications</h5><p>As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.</p><p>Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances. The hepatobiliary phase requires a 1-hour delay.</p><p>Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. <a href="/articles/gadofosveset-trisodium-1">Gadofosveset trisodium (Ablavar)</a> has approximately 3-4x the relaxivity of gadobenate dimeglumine, but is considered a blood pool agent and its commercial availability is limited.</p><p>The high relaxivity of gadobenate dimeglumine also makes it a preferred agent for imaging</p><ul>- +</ul><h5>Indications</h5><p>As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.</p><p>Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances but requires a 1-hour delay for imaging acquisition. </p><p>Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. <a href="/articles/gadofosveset-trisodium-1">Gadofosveset trisodium (Ablavar)</a> has approximately 3-4x the relaxivity of gadobenate dimeglumine but is considered a blood pool agent and its commercial availability is limited.</p><p>The high relaxivity of gadobenate dimeglumine also makes it a preferred agent for imaging:</p><ul>
-<li>pelvis fistula imaging</li>- +<li><a title="Perianal fistula protocol (MRI)" href="/articles/perianal-fistula-protocol-mri">MR perianal fistula</a></li>
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