Ganglion cysts are the most common mass-like lesions of the hand and wrist.
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Epidemiology
They are the most common soft-tissue tumors of the hand and occur most frequently in the age group of 20-40 years. Women are more commonly affected 1-3.
Risk factors
Ganglion cysts of the hand and wrists are more likely to develop in gymnasts 1.
Diagnosis
The diagnosis is usually made clinically and can be confirmed with ultrasound or MRI.
Clinical presentation
A typical presentation of wrist and hand ganglia is a lump of varying size, sometimes growing with activity and shrinking with rest. Due to mass effects, they might cause pain, paresthesia, impaired function or cosmetic problems 1,2.
Pathology
Ganglion cysts of the wrist and hand typically feature a pedicle that connects them to the joint. Otherwise, they are well-defined, sharply marginated, lobulated, uni- or multilocular. They are surrounded by dense connective tissue, lack a synovial lining and are filled with viscous, mucoid material 1-3.
Etiology
The fluid within the ganglion cysts is thicker and different from the synovial fluid in the joint. The pathogenesis is controversial and comprises the following theories 3:
cyst formation as a consequence of stress, tissue irritation or a degenerative process
mucin secretion by mesenchymal cells
mucoid degeneration of the extra-articular tissues
Location
Typical locations of wrist ganglia include the following 1,4:
volar aspect of the wrist between the radial artery and the flexor carpi radialis
dorsum of the wrist with the scapholunate ligament and dorsal capsule as the most frequent sites of origin
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other volar locations include
scaphotrapezial joint
trapeziometacarpal joint
flexor tendon sheath
There is some discordance as to whether most wrist ganglia are found at the volar aspect between the radial artery and the flexor carpi radialis tendon or the dorsum of the wrist 1,4.
Radiographic features
Plain radiograph
Plain radiographs of the hand and wrist show the bony structures and cannot visualize a ganglion cyst as such. They might, however, show important differential diagnoses.
Ultrasound
On ultrasound ganglion cysts are typically hypoechoic to anechoic and show well-defined, smooth-walled margins 5. They might show internal septations and display an acoustic enhancement.
MRI
MRI is an accurate modality for the visualization and evaluation of ganglion cysts with a reported sensitivity and specificity of 94.7% and 94.4% 1,5. The typical appearance is that of a well-defined, multiloculated cystic lesion with a stalk.
T1: usually hypointense but will depend on protein content
T2: hyperintense
PDFS/T2FS: hyperintense
Treatment and prognosis
Spontaneous resolution occurs in up to 50% of cases. Therefore management options depend vastly on clinical symptoms and patient wishes. They do not require treatment as such, only in case of pain, impaired function or cosmetic reasons.
Treatment options include watchful waiting, US-guided aspiration as well as arthroscopic or surgical excision the latter offering improved resolution but being most invasive 1-3.
History and etymology
Hippocrates is credited with the first description of ganglion cysts that derives from ancient Greek γάγγλιον, "knot under the skin".
In 1743 the German surgeon, botanist and anatomist Lorenz Heister gave several management recommendations for wrist ganglia: it could be dispersed by rubbing the ganglion each morning with saliva, binding a piece of lead upon it for several weeks 3 or rubbing it with the hand of a dead man.
Another recommendation, according to an urban legend, is that one can get rid of them by whacking them with a big book (like a bible), hence the nickname 'bible bump' or 'bible cyst'. For obvious reasons, this type of treatment is no longer recommended.
Differential diagnosis
Conditions that can mimic the presentation and/or the appearance of wrist and hand ganglia include 5: