Gleason score

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The Gleason score determines the histological grading of prostate cancer. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.

1 = least aggressive.
5 = most aggressive.

These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication ~~to publication~~-to-publication. For ~~examples~~ example ¹:

2 - 4 (low grade)
- 100% progression free at 5 years
- 95.6% progression free at 10 years
5 - 6
- 96.9% progression free at 5 years
- 81.9% progression free at 10 years
7
- 76.9% progression free at 5 years
- 51.4% progression free at 10 years
8 - 9

Etymology

Named after Donald Gleason, ~~: American~~ American (US) pathologist (1920 - 2008).

-<p style="PADDING-RIGHT: 5px; BACKGROUND-POSITION: 2px 2px; PADDING-LEFT: 5px; MIN-HEIGHT: 1em; BACKGROUND-IMAGE: url(http://radiopaedia.org/vendor/wymeditor/iframe/radiopaedia/lbl-p.png); PADDING-BOTTOM: 5px; MARGIN: 10px; PADDING-TOP: 8px; BACKGROUND-COLOR: rgb(255,255,255); background-origin: initial; background-clip: initial">The <strong>Gleason score</strong> determines the histological grading of <a href="/articles/prostatic-adenocarcinoma" title="prostate cancer">prostate cancer</a>. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.</p><ul style="PADDING-RIGHT: 5px; BACKGROUND-POSITION: 2px 2px; PADDING-LEFT: 5px; PADDING-BOTTOM: 0px; MARGIN: 10px; BORDER-LEFT: rgb(185,196,208) 20px solid; PADDING-TOP: 0px; BACKGROUND-COLOR: rgb(255,255,255); background-origin: initial; background-clip: initial"><li>1 = least aggressive.</li><li>5 = most aggressive.</li></ul><p style="PADDING-RIGHT: 5px; BACKGROUND-POSITION: 2px 2px; PADDING-LEFT: 5px; MIN-HEIGHT: 1em; BACKGROUND-IMAGE: url(http://radiopaedia.org/vendor/wymeditor/iframe/radiopaedia/lbl-p.png); PADDING-BOTTOM: 5px; MARGIN: 10px; PADDING-TOP: 8px; BACKGROUND-COLOR: rgb(255,255,255); background-origin: initial; background-clip: initial">These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication to publication. For examples <sup>1</sup>: </p><ul style="PADDING-RIGHT: 5px; BACKGROUND-POSITION: 2px 2px; PADDING-LEFT: 5px; PADDING-BOTTOM: 0px; MARGIN: 10px; BORDER-LEFT: rgb(185,196,208) 20px solid; PADDING-TOP: 0px; BACKGROUND-COLOR: rgb(255,255,255); background-origin: initial; background-clip: initial"><li>2 - 4 (low grade)<ul><li>100% progression free at 5 years </li><li>95.6% progression free at 10 years </li></ul></li><li>5 - 6<ul style="background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: rgb(255, 255, 255); padding-top: 0px; padding-right: 5px; padding-bottom: 0px; padding-left: 5px; margin-top: 10px; margin-right: 10px; margin-bottom: 10px; margin-left: 10px; border-left-width: 20px; border-left-style: solid; border-left-color: rgb(185, 196, 208); background-position: 2px 2px; background-repeat: no-repeat no-repeat; "><li>96.9% progression free at 5 years </li><li>81.9% progression free at 10 years </li></ul></li><li>7<ul style="background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: rgb(255, 255, 255); padding-top: 0px; padding-right: 5px; padding-bottom: 0px; padding-left: 5px; margin-top: 10px; margin-right: 10px; margin-bottom: 10px; margin-left: 10px; border-left-width: 20px; border-left-style: solid; border-left-color: rgb(185, 196, 208); background-position: 2px 2px; background-repeat: no-repeat no-repeat; "><li>76.9% progression free at 5 years </li><li>51.4% progression free at 10 years </li></ul></li><li>8 - 9<br /><ul style="background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: rgb(255, 255, 255); padding-top: 0px; padding-right: 5px; padding-bottom: 0px; padding-left: 5px; margin-top: 10px; margin-right: 10px; margin-bottom: 10px; margin-left: 10px; border-left-width: 20px; border-left-style: solid; border-left-color: rgb(185, 196, 208); background-position: 2px 2px; background-repeat: no-repeat no-repeat; "><li>59.1% progression free at 5 years </li><li>34.9% progression free at 10 years </li></ul></li></ul><h4>Etymology</h4><p>Named after <strong>Donald Gleason</strong> : American (US) pathologist (1920 - 2008)</p><h4>See also</h4><ul><li><a href="/articles/prostatic-adenocarcinoma" title="prostate cancer">prostate cancer</a><ul><li><a href="/articles/prostate_cancer_staging" title="Prostate cancer staging">prostate cancer staging</a></li></ul></li></ul>
+<p>The <strong>Gleason score</strong> determines the histological grading of <a href="/articles/prostatic-carcinoma-1">prostate cancer</a>. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.</p><ul>
+<li>1 = least aggressive</li>
+<li>5 = most aggressive</li>
+</ul><p>These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication-to-publication. For example <sup>1</sup>: </p><ul>
+<li>2 - 4 (low grade)<ul>
+<li>100% progression free at 5 years </li>
+<li>95.6% progression free at 10 years </li>
+</ul>
+</li>
+<li>5 - 6<ul>
+<li>96.9% progression free at 5 years </li>
+<li>81.9% progression free at 10 years </li>
+</ul>
+</li>
+<li>7<ul>
+<li>76.9% progression free at 5 years </li>
+<li>51.4% progression free at 10 years </li>
+</ul>
+</li>
+<li>8 - 9<ul>
+<li>59.1% progression free at 5 years </li>
+<li>34.9% progression free at 10 years </li>
+</ul>
+</li>
+</ul><h4>Etymology</h4><p>Named after <strong>Donald Gleason,</strong> American (US) pathologist (1920 - 2008).</p><h4>See also</h4><ul><li>
+<a href="/articles/prostatic-carcinoma-1">prostate cancer</a><ul><li><a href="/articles/prostate_cancer_staging">prostate cancer staging</a></li></ul>
+</li></ul>