Question 2251
{"accessible":false,"alternatives":[{"id":11151,"text":"chemotherapy with bevacizumab followed by radiotherapy"},{"id":11152,"text":"chemotherapy with temozolomide followed by radiotherapy"},{"id":11153,"text":"radiotherapy with concurrent and post-radiotherapy chemotherapy with bevacizumab"},{"id":11154,"text":"radiotherapy with concurrent and post-radiotherapy chemotherapy with temozolomide"},{"id":11155,"text":"radiotherapy followed by post-radiotherapy chemotherapy with bevacizumab"},{"id":11156,"text":"radiotherapy followed by post-radiotherapy chemotherapy with temozolomide"}],"archived":false,"correctAlternativeId":11154,"explanation":"\u003cp\u003eAlthough there are variations,\u0026nbsp;the originally described Stupp protocol comprises:\u0026nbsp;\u003c/p\u003e\u003cul\u003e\n\u003cli\u003eradiotherapy\u003cul\u003e\n\u003cli\u003etotal 60 Gy\u003c/li\u003e\n\u003cli\u003e2 Gy per daily fraction (Monday to Friday) over 6 weeks\u003c/li\u003e\n\u003c/ul\u003e\n\u003c/li\u003e\n\u003cli\u003etemozolomide\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https://radiopaedia.org/articles/missing?article%5Btitle%5D=temozolomide\"\u003e\u003c/a\u003eduring radiotherapy:\u0026nbsp;75 mg per square metre of body-surface area per day, 7 days per week\u003c/li\u003e\n\u003cli\u003epost-radiotherapy (adjuvant):\u0026nbsp;six cycles consisting of 150-200 mg per square metre for 5 days during each 28-day cycle\u003c/li\u003e\n\u003c/ul\u003e\n\u003c/li\u003e\n\u003c/ul\u003e","id":2251,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2768","nextQuestionPath":"/articles/glioblastoma-idh-wildtype/questions/2250","relatedArticles":[{"id":34959,"title":"Tumour pseudoprogression (brain tumours)","link":"/articles/tumour-pseudoprogression-brain-tumors?lang=gb"},{"id":42300,"title":"Stupp protocol","link":"/articles/stupp-protocol?lang=gb"}],"alsoUsedIn":[{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-neuroradiology-review-course/pages/1169"},{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-brain-mri-review-course-2015-online-video/pages/1169"},{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"}],"stem":"\u003cp\u003eThe Stupp protocol for the treatment of high-grade gliomas comprises:\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2251"}],"attemptsPercentages":[{"alternativeId":"11151","percentage":4},{"alternativeId":"11155","percentage":3},{"alternativeId":"11152","percentage":11},{"alternativeId":"11154","percentage":66},{"alternativeId":"11156","percentage":11},{"alternativeId":"11153","percentage":5}],"promptToLogin":false,"questionManager":false,"articleId":"glioblastoma-idh-wildtype"}