Hand-foot syndrome (chemotherapy)

Changed by Rohit Sharma, 27 Jun 2018

Updates to Article Attributes

Body was changed:

Hand-foot syndrome, also known as palmar-plantar erythrodysesthesia or Burgdorf reaction,  is is a benign aseptic self-limiting complication of many chemotherapeutic agents characterised by a widespread erythema, oedema and ulceration of the hands and feet. 

Causative drugs

Many chemotherapeutic agents have been described as causing hand-foot syndrome including 1

  • 5-fluorouracil
  • capecitabine
  • cyclophosphamide
  • cytarabine
  • docetaxel
  • etoposide
  • hydroxyurea
  • liposomal doxorubicin
  • mercaptopurine
  • methotrexate
  • paclitaxel
  • sorafenib
  • sunitinib
  • tegafur
  • vinorelbine

Disambiguation

Hand-foot syndrome in the setting of chemotherapy should not be confused with:

  • -<p><strong>Hand-foot syndrome</strong>, also known as <strong>palmar-plantar erythrodysesthesia</strong> or <strong>Burgdorf reaction</strong>,  is a benign aseptic self-limiting complication of many chemotherapeutic agents characterised by a widespread erythema, oedema and ulceration of the hands and feet. </p><h4>Causative drugs</h4><p>Many chemotherapeutic agents have been described as causing hand-foot syndrome including <sup>1</sup>: </p><ul>
  • +<p><strong>Hand-foot syndrome</strong>, also known as <strong>palmar-plantar erythrodysesthesia</strong> or <strong>Burgdorf reaction</strong>, is a benign aseptic self-limiting complication of many chemotherapeutic agents characterised by a widespread erythema, oedema and ulceration of the hands and feet. </p><h4>Causative drugs</h4><p>Many chemotherapeutic agents have been described as causing hand-foot syndrome including <sup>1</sup>: </p><ul>

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