Iodine-131 iobenguane, trade name Azedra, sometimes referred to as I-131 MIBG, is a theranostic (i.e. both therapeutic and diagnostic) agent used for the treatment of unresectable phaeochromocytomas, paragangliomas, carcinoid, and neuroblastomas. It is created using the high specificity Ultratrace synthesis method to produce a high proportion of MIBG bound to the radiopharmaceutical Iodine-131, allowing specific targeting of the noradrenaline transporter.
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Characteristics
Decay:
similar characteristics as I-131 used for thyroid treatment
beta minus emission – cytotoxic effects
gamma emission with photopeak 364 keV usable for imaging
half life of 8 days
Predominantly renal/urinary excretion.
Use
I-131 iobenguane has been shown to reduce noradrenaline-secreting tumour size and alleviate metabolic effects such as hypertension from catecholamine-secreting tumours.
Pretreatment scan is performed with iobenguane scan (I-123 MIBG) to ensure a viable target. Then, a small dosimetry dose of I-131 iobenguane is used to calculate the therapeutic dose. Treatment is given via intravenous infusion in two doses, three months apart.
Potential side effects
myelosuppression, including neutropenia (occasionally febrile), anaemia, and thrombocytopenia
nausea, vomiting, fatigue
rare: hypothyroidism, transient hypertension (from release of hormones as tumour tissue is destroyed), decreased renal function, pneumonitis
not approved for pregnant patients
History and etymology
Azedra was FDA-approved in 2018 for the treatment of patients 12 years and older with unresectable metastatic phaeochromocytomas and paragangliomas. It is manufactured by Progenics Pharmaceuticals, Inc., a Lantheus company, in the Unites States. In August 2023, Lantheus disclosed in regulatory filings that they will ultimately stop production of Azedra, continuing into the first quarter of 2024 to provide doses to patients 6,7.