A leukemoid reaction refers to a marked increase in white blood cells (>50000 cells/mL), typically neutrophils, which manifests as an acute inflammatory reaction that can mimic leukemia.
Pathology
Leukemoid reactions often occur from accelerated release of cells from the bone marrow.
Features that differentiate it from leukemia include:
no immature cells
no basophilia
no monocytosis
no increase in increased leukocyte alkaline phosphatase (LAP)
absence of the BCR-ABL1 translocation
bone marrow is hypercellular but otherwise normal
Etiology
severe infection
intoxication
other malignancies
severe hemorrhage
acute hemolysis
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