Lugano classification (PET-CT treatment response)
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The Lugano classification is a lymphoma staging system for non-Hodgkin and Hodgkin lymphoma. This article outlines the classification's response to treatment based on PET-CT.
Also included in the classification are staging and response to treatment based on CT.
Scoring system
The Lugano classification recommends a five-point scale (see alsothe Deauville five-point scale) for for reporting response assessment withby FDG PET-CT:
- no uptake or no residual uptake (when used interim)
- slight uptake, but below blood pool (mediastinum)
- uptake above mediastinal, but below or equal to uptake in the liver
- uptake slightly to moderately higher than liver
- markedly increased uptake or any new lesion (on response evaluation)
Non-progressive disease
- complete metabolic response (CMR)
- score of 1, 2 or 3 in nodal or extranodal sites with or without a residual mass
- partial metabolic response (PMR)
- score of 4 or 5 with reduced uptake compared with baseline and residual mass(es) of any size
- stable disease or no metabolic response
- score of 4 or 5 with no obvious change in FDG uptake
Progressive disease
- score 4 or 5 in any lesion with an increase in intensity of FDG uptake from baseline (and/or new FDG-avid foci consistent with lymphoma)
-<p>The<strong> Lugano classification</strong> is a lymphoma staging system resulting from recommended changes in 2011 to the <a href="/articles/cotswolds-modified-ann-arbor-classification-1">Cotswolds modified Ann Arbor staging</a>. This article outlines the classification's <strong>response to treatment based on PET-CT</strong>. </p><p>Also included in the classification are <a href="/articles/lugano-classification-staging">staging</a> and response to <a href="/articles/lugano-classification-response-to-treatment-on-ct">treatment based on CT</a>.</p><h5>Scoring system</h5><p>The Lugano classification recommends a five-point scale (see also <a href="/articles/deauville-five-point-scale">Deauville five-point scale</a>) for response assessment with <a href="/articles/positron-emission-tomography">FDG PET-CT</a>:</p><ol>- +<p>The<strong> Lugano classification</strong> is a <a title="Lymphoma (staging)" href="/articles/lymphoma-staging-1">lymphoma staging</a> system for non-Hodgkin and <a title="Staging of Hodgkin lymphoma" href="/articles/lymphoma-staging-1">Hodgkin lymphoma</a>. This article outlines <a title="Lugano staging classification" href="/articles/lugano-staging-classification-1">the classification</a>'s <strong>response to treatment based on PET-CT</strong>. </p><p>Also included in the classification are <a href="/articles/lugano-classification-staging">staging</a> and response to <a href="/articles/lugano-classification-response-to-treatment-on-ct">treatment based on CT</a>.</p><h5>Scoring system</h5><p>The Lugano classification recommends the <a href="/articles/deauville-five-point-scale">Deauville five-point scale</a> for reporting response by <a href="/articles/positron-emission-tomography">FDG PET-CT</a>:</p><ol>
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