Metachronous primary lung carcinoma

Metachronous primary lung carcinoma of usually referred to tumors with the same histology which are "separated in time" when there has been a disease-free interval between cancers.

It definition as been "variably" defined in literature and can include

  • time interval of at least 2 years or the second tumor is found in a different segment, lobe, or lung with no carcinoma in the lymphatics common to both; and there is no evidence of extrapulmonary metastasis at the time of diagnosis 1.
  • SEER database recommendation: 2-month period to distinguish between synchronous and metachronous multiple primaries.
  • IARC suggestion: registration of synchronous tumors diagnosed in an interval of less than 6 months (or metachronous if more than 6 months) if arising in different sites.
  • "the latter two suggestions have been for "any" cancer and not just lung cancer"

Average lifelong rate of developing a "new primary lung cancer" is thought o approximates 1% and 6% per year after radical therapy for non-small-cell lung cancer and small cell lung cancer, respectively 4.

  • pulmonary metastasis from original initial lung cancer
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Article information

rID: 69110
System: Chest
Synonyms or Alternate Spellings:
  • Metachronous lung cancers
  • Metachronous lung cancer
  • Metachronous lung carcinomas
  • Metachronous lung carcinoma
  • Metachronous primary lung cancers
  • Metachronous primary lung carcinomas
  • Metachronous primary lung cancer

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Cases and figures

  • Case 1: metachronous lung cancer post-pneumonectomy
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