Myxoid degeneration of a leiomyoma

Myxoid degeneration of a leiomyoma is one of the rarer types of degeneration that can occur in a standard uterine leiomyoma. This term is related but not identical to the term myxoid uterine leiomyoma

While this type of degeneration is generally considered rare. The higher end of prevalence for this type of degeneration has been reported up to 50% of all degenerations 5.

Fibroids that have undergone myxoid degeneration are filled with a gelatinous material and can be difficult to differentiate from fibroids that have undergone cystic degeneration; however, they typically appear as more complex cystic masses. They appear hypocellular with a myxoid matrix 6.

On pelvic MRI, the myxoid material usually demonstrates 2:

  • T1: low signal intensity 
  • T2: usually high signal intensity 2-3 with a peripheral low signal intensity 6
  • T1 C+ (Gd): there is minimal or no enhancement 2-3

The above signal changes are present as intralesional change 4 amongst the background low T2 signal of non-myxoid components.

Certain malignant uterine tumours also contain myxoid degeneration and include:

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Article information

rID: 17642
System: Gynaecology
Tag: cases
Synonyms or Alternate Spellings:
  • Myxoid degeneration of leiomyoma
  • Myxoid degeneration of leiomyomas
  • Myxoid degeneration of a uterine leiomyoma
  • Myxoid degeneration of uterine leiomyoma
  • Myxoid degeneration in fibroids
  • Myxoid degeneration in uterine fibroids

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