Neuronal nuclear antigen (NeuN)

Changed by Frank Gaillard, 21 Aug 2023

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Disclosures - updated 6 Dec 2022:

Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software in multiple sclerosis: finished Oct 2021 (past)

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Neuronal nuclear antigen (NeuN)

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Neuronal nuclear antigen (NeuN) is a protein expressed in mature (post-mitotic) neurones and is commonly used as an immunohistochemical target to identify neuronal differentiation (e.g. in ganglioglioma and gangliocytomas).

It is primarily expressed in the nuclei of neurones with less pronounced expression in the cytoplasm and dendrites and axons ¹.

+Neuronal nuclear antigen (NeuN) is a protein expressed in mature (post-mitotic) neurones and is commonly used as an <a href="/articles/immunohistochemistry" title="Immunohistochemistry">immunohistochemical</a> target to identify neuronal differentiation (e.g. in <a href="/articles/ganglioglioma" title="Ganglioglioma">ganglioglioma</a> and <a href="/articles/gangliocytoma" title="Gangliocytomas">gangliocytomas</a>). It is primarily expressed in the nuclei of neurones with less pronounced expression in the cytoplasm and dendrites and axons 1.

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Published At was set to 2023-08-21T06:59:21.313Z.

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1. Gusel'nikova V & Korzhevskiy D. NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker. Acta Naturae. 2015;7(2):42-7. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463411">PMC4463411</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/26085943">Pubmed</a>

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