Perivascular epithelioid cell tumours (PEComas)

A.Prof Frank Gaillard et al.

Perivascular epithelioid cells tumours (PEComas) are a group of related mesenchymal tumours and tumour-like conditions found in many locations. This group includes:


PEComas are far more common in females 4




All PEComas share similar and distinctive cellular morphology – peripheral epitheloid cells – which have no counterpart in normal tissue 4. These tumours appear as sheets and nests of epithelioid or spindle-shaped cells associated with blood vessel walls. They have granular eosinophilic cytoplasms. 


PEComas are characterised by immunoreactivity to smooth muscle and melanocytic markers 4.

  • smooth muscle: actin, desmin
  • melanocytic: HMB-45, melan-A
Treatment and prognosis

PEComas usually behave in a benign fashion although local recurrence and even malignant behaviour are encountered, mimicking malignant sarcomas. 

Surgical excision is usually curative. 

Share article

Article information

rID: 9985
Tags: cases, refs
Synonyms or Alternate Spellings:
  • Perivascular epithelioid cell tumours (PEComa)
  • PEComa
  • PEComas
  • Perivascular epithelioid cell tumours (PEComas)
  • Perivascular epithelioid cell tumors (PEComa)
  • Perivascular epithelioid cell tumor (PEComa)
  • Peri-vascular epithelioid cell tumor (PEComa)

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.