REACT syndrome
Updates to Article Attributes
Body
was changed:
Reversible acute cerebellar toxicity (REACT) is a potentially reversible acute encephalopathic syndrome 1-2.
Epidemiology
REACT is a rare syndrome that has been associated with several opioid and chemotherapeutic agents, including Minnelide 1-2.
Clinical presentation
Patients typically present with cerebellar symptoms, including gait ataxia, dysmetria, and balance and speech impairment, which may be accompanied by confusion 1.
Radiographic features
MRI
REACT presents on MRI with diffuse and symmetric FLAIR hyperintense changes with restricted diffusion of the cerebellar cortex 1. It typically lacks involvement of the cerebellar nuclei and supratentorial structures 1.
Treatment and prognosis
The syndrome may be reversible with discontinuation of the causative drug.
Differential diagnosis
-
Cerebellarcerebellar infarction: irreversible and occurring in typical arterial territories. - acute cerebellitis: usually seen in children following viral illness
-<p><strong>Reversible acute cerebellar toxicity (REACT) </strong>is a potentially reversible acute encephalopathic syndrome <sup>1-2</sup>. </p><h4>Epidemiology</h4><p>REACT is a rare syndrome that has been associated with several opioid and chemotherapeutic agents, including Minnelide <sup>1-2</sup>.</p><h4>Clinical presentation</h4><p>Patients typically present with cerebellar symptoms, including gait ataxia, dysmetria, and balance and speech impairment, which may be accompanied by confusion <sup>1</sup>.</p><h4>Radiographic features</h4><h5>MRI</h5><p>REACT presents on MRI with diffuse and symmetric FLAIR hyperintense changes with restricted diffusion of the cerebellar cortex <sup>1</sup>. It typically lacks involvement of the cerebellar nuclei and supratentorial structures <sup>1</sup>.</p><h4>Treatment and prognosis</h4><p>The syndrome may be reversible with discontinuation of the causative drug.</p><h4>Differential diagnosis</h4><p><a href="/articles/cerebellar-infarction">Cerebellar infarction</a>: irreversible and occurring in typical arterial territories.</p>- +<p><strong>Reversible acute cerebellar toxicity (REACT) </strong>is a potentially reversible acute encephalopathic syndrome <sup>1-2</sup>. </p><h4>Epidemiology</h4><p>REACT is a rare syndrome that has been associated with several opioid and chemotherapeutic agents, including Minnelide <sup>1-2</sup>.</p><h4>Clinical presentation</h4><p>Patients typically present with cerebellar symptoms, including gait ataxia, dysmetria, and balance and speech impairment, which may be accompanied by confusion <sup>1</sup>.</p><h4>Radiographic features</h4><h5>MRI</h5><p>REACT presents on MRI with diffuse and symmetric FLAIR hyperintense changes with restricted diffusion of the cerebellar cortex <sup>1</sup>. It typically lacks involvement of the cerebellar nuclei and supratentorial structures <sup>1</sup>.</p><h4>Treatment and prognosis</h4><p>The syndrome may be reversible with discontinuation of the causative drug.</p><h4>Differential diagnosis</h4><ul>
- +<li>
- +<a href="/articles/cerebellar-infarction">cerebellar infarction</a>: irreversible and occurring in typical arterial territories</li>
- +<li>
- +<a title="Acute cerebellitis" href="/articles/acute-cerebellitis">acute cerebellitis</a>: usually seen in children following viral illness</li>
- +</ul>
Unable to process the form. Check for errors and try again.