Citation, DOI and article data
Synovial chondrosarcoma refers to a very rare malignant cartilaginous neoplasm arising from the synovium.
There can be a wide spectrum in age of presentation from from 25-75 years of age. A slight male predilection may be present.
It can either as a primary lesion (primary synovial chondrosarcoma) or secondary to synovial chondromatosis. The relative risk for progression from synovial chondromatosis to malignancy is estimated to be 5% or less.
Synovial chondrosarcoma and synovial chondromatosis can have a similar appearance at microscopy
Can vary but most cases involve the knee, hip, or shoulder. Rare occurrences in smaller joints have been reported.
Can be very similar to synovial chondromatosis.
May be seen as a juxta-articular region with pattern of cartilaginous calcifications similar to synovial chondromatosis.
Signal characteristics of particular nodules include
- T1: low to intermediate signal intensity of nodules
- T2: high signal intensity in general with hypointense calcifications
On contrast to synovial chondromatosis, some imaging features are suggestive of the presence of the malignant neoplasm.
- may erode cortical bone: synovial chondrosarcoma often demonstrates cortical destruction with marrow invasion
- extra-articular extension is more often present in more aggressive lesions, although it is not a specific sign of malignancy
- metastases are indicative of malignancy.
Treatment and prognosis
It is a malignant lesions which can metastasize. Treatment is similar to that of other sarcomas and includes amputation or extra-articular resection with wide surgical margins.
- 1. Schlachter TR, Wu Q, Matlyuk-Urman Z. AIRP best cases in radiologic-pathologic correlation: synovial chondrosarcoma. Radiographics. 2011;31 (7): 1883-8. doi:10.1148/rg.317105210 - Pubmed citation
- 2. Coleman H, Chandraratnam E, Morgan G et-al. Synovial chondrosarcoma arising in synovial chondromatosis of the temporomandibular joint. Head Neck Pathol. 2013;7 (3): 304-9. doi:10.1007/s12105-013-0439-y - Free text at pubmed - Pubmed citation
- 3. Zamora EE, Mansor A, Vanel D et-al. Synovial chondrosarcoma: report of two cases and literature review. Eur J Radiol. 2009;72 (1): 38-43. doi:10.1016/j.ejrad.2009.05.029 - Pubmed citation
- 4. Yao MS, Chang CM, Chen CL et-al. Synovial chondrosarcoma arising from synovial chondromatosis of the knee. JBR-BTR. 2013;95 (6): 360-2. Pubmed citation
- 5. Rybak LD, Khaldi L, Wittig J et-al. Primary synovial chondrosarcoma of the hip joint in a 45-year-old male: case report and literature review. Skeletal Radiol. 2011;40 (10): 1375-81. doi:10.1007/s00256-011-1172-9 - Pubmed citation
- 6. Kenan S, Abdelwahab IF, Klein MJ et-al. Case report 817: Synovial chondrosarcoma secondary to synovial chondromatosis. Skeletal Radiol. 1994;22 (8): 623-6. Pubmed citation