Tc-99m sestamibi
Updates to Article Attributes
Body
was changed:
Tc-99m sestamibi is one of the technetium radiopharmaceuticals.
Characteristics
- photon energy: 140 KeV
- physical half life: 6 hours
- normal distribution: thyroid, parathyroid, heart
- excretion: hepatobiliary
- target organ: colon, kidneys, bladder, gallbladder
Uses, doses and timings
- parathyroid scan
- adult dose:
20740 MBq (20 mCi) IV - timing: early scan at 15 min; delayed scan at 2 hours
Tc99m-sestamibi is a radiopharmaceutical that is taken up by cells with a high concentration of mitochondria i.e. highly cellular/metabolically active tissues such as the heart but also abnormal tissues such as oxyphil cell parathyroid adenomas, myeloma and breast cancer (the basis of so-called scintimammography). This latter technique has a high specificity for cancer but uses significant radiation dose.
When the radiopharmaceutical is used for parathyroid imaging, immediate and delayed imaging of the neck and mediastinum is performed; parathyroid adenomas are best demonstrated on delayed imaging (1-2 hours).
-<p>Tc-99m sestamibi is one of the <a href="/articles/technetium-radiopharmaceuticals">technetium radiopharmaceuticals</a>. </p><h4>Characteristics</h4><ul>- +<p><strong>Tc-99m sestamibi</strong> is one of the <a href="/articles/technetium-radiopharmaceuticals">technetium radiopharmaceuticals</a>. </p><h4>Characteristics</h4><ul>
-<li>adult dose: 20 mCi IV</li>- +<li>adult dose: 740 MBq (20 mCi) IV</li>
-</ul><p>Tc99m-sestamibi is a radiopharmaceutical that is taken up by cells with a high concentration of mitochondria i.e. highly cellular/metabolically active tissues such as the heart but also abnormal tissues such as oxyphil cell parathyroid adenomas, myeloma and breast cancer (the basis of so-called scintimammography). This latter technique has a high specificity for cancer but uses significant radiation dose. </p><p>When the radiopharmaceutical is used for parathyroid imaging, immediate and delayed imaging of the neck and mediastinum is performed - <a title="Parathyroid adenomas" href="/articles/parathyroid-adenoma">parathyroid adenomas</a> are best demonstrated on delayed imaging (1-2 hours).</p>- +</ul><p>Tc99m-sestamibi is a radiopharmaceutical that is taken up by cells with a high concentration of mitochondria i.e. highly cellular/metabolically active tissues such as the heart but also abnormal tissues such as oxyphil cell parathyroid adenomas, myeloma and breast cancer (the basis of so-called scintimammography). This latter technique has a high specificity for cancer but uses significant radiation dose. </p><p>When the radiopharmaceutical is used for parathyroid imaging, immediate and delayed imaging of the neck and mediastinum is performed; <a href="/articles/parathyroid-adenoma">parathyroid adenomas</a> are best demonstrated on delayed imaging (1-2 hours).</p>
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